Clobetasone

Clobetasone

Clinical data
Trade names	Eumovate
Other names	(8S,9R,10S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-9-fluoro-17-hydroxy-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthrene-3,11-dione
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of administration	topical
ATC code	D07AB01 (WHO) S01BA09 (WHO)
Identifiers
IUPAC name (1R,2S,10S,11S,13S,14R,15S)-14-(2-chloroacetyl)-1-fluoro-14-hydroxy-2,13,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-diene-5,17-dione
CAS Number	54063-32-0 Y
PubChem CID	71387
ChemSpider	64482 Y
UNII	LT69WY1J6D
KEGG	D07717 Y
CompTox Dashboard (EPA)	DTXSID601023875
ECHA InfoCard	100.053.576
Chemical and physical data
Formula	C22H26ClFO4
Molar mass	408.89 g·mol−1
3D model (JSmol)	Interactive image
SMILES ClCC(=O)[C@@]2(O)[C@@H](C)C[C@H]1[C@H]4[C@](F)(C(=O)C[C@@]12C)[C@@]/3(/C(=C\C(=O)\C=C\3)CC4)C
InChI InChI=1S/C22H26ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-16,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,19-,20-,21-,22-/m0/s1 Y Key:XXIFVOHLGBURIG-OZCCCYNHSA-N Y
(verify)

Clobetasone (INN^[1]) is a corticosteroid used in dermatology, for treating such skin inflammation as seen in eczema, psoriasis and other forms of dermatitis, and ophthalmology. Topical clobetasone butyrate has shown minimal suppression of the hypothalamic–pituitary–adrenal axis.^[2]

It is available as clobetasone butyrate under the brand names Eumosone or Eumovate^[3] both manufactured by GlaxoSmithKline.

Trimovate also contains oxytetracycline, an antibiotic, and nystatin, an antifungal.^[4]