Clocortolone

Clocortolone pivalate
Clinical data
Trade names	Cloderm
AHFS/Drugs.com	Consumer Drug Information
Routes of; administration	Topical
ATC code	D07AB21 (WHO) ;
Legal status
Legal status	US: ℞-only;
Identifiers
	IUPAC name [2-(9-Chloro-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] 2,2-dimethylpropanoate;
CAS Number	4828-27-7 ;
PubChem CID	5282493;
DrugBank	DB00838 ;
ChemSpider	4445634 ;
UNII	N8ZUB7XE0H;
KEGG	D02287 ;
ChEBI	CHEBI:59583 ;
ChEMBL	ChEMBL1201366 ;
CompTox Dashboard (EPA)	DTXSID901333489 ;
ECHA InfoCard	100.023.096
Chemical and physical data
Formula	C27H36ClFO5
Molar mass	495.03 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC(=O)[C@@H]3[C@]2(C[C@H](O)[C@]4(Cl)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C)C(C)(C)C;
	InChI InChI=1S/C27H36ClFO5/c1-14-9-16-17-11-19(29)18-10-15(30)7-8-26(18,6)27(17,28)21(32)12-25(16,5)22(14)20(31)13-34-23(33)24(2,3)4/h7-8,10,14,16-17,19,21-22,32H,9,11-13H2,1-6H3/t14-,16+,17+,19+,21+,22-,25+,26+,27+/m1/s1 ; Key:SXYZQZLHAIHKKY-GSTUPEFVSA-N ;
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Clocortolone (Cloderm) is a topical steroid.^[1] It is used in the form of an ester, clocortolone pivalate, and applied as a cream.^[2] It is used for the treatment of dermatitis and is considered a medium-strength corticosteroid. It is unusual among steroids in that it contains a chlorine atom and a fluorine atom.

^ Nierman MM (June 1981). "Safety and efficacy of clocortolone pivalate 0.1 percent cream in the treatment of atopic dermatitis, contact dermatitis, and seborrheic dermatitis". Cutis. 27 (6): 670–1. PMID 6453703.
^ Drugs.com: Clocortolone topical

[1] Nierman MM (June 1981). "Safety and efficacy of clocortolone pivalate 0.1 percent cream in the treatment of atopic dermatitis, contact dermatitis, and seborrheic dermatitis". Cutis. 27 (6): 670–1. PMID 6453703.

[2] Drugs.com: Clocortolone topical

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