![]() | |
![]() | |
Clinical data | |
---|---|
Pronunciation | /kləˈpɪdəɡrɛl, kloʊ-/[1] |
Trade names | Plavix, Iscover, others[2] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601040 |
License data |
|
Pregnancy category |
|
Routes of administration | By mouth |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | >50% |
Protein binding | 94–98% |
Metabolism | Liver |
Onset of action | 2 hours[10] |
Elimination half-life | 7–8 hours (inactive metabolite) |
Duration of action | 5 days[10] |
Excretion | 50% Kidney 46% bile duct |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
PDB ligand | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.127.841 |
Chemical and physical data | |
Formula | C16H16ClNO2S |
Molar mass | 321.82 g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
Clopidogrel, sold under the brand name Plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk.[10] It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent (dual antiplatelet therapy).[10] It is taken by mouth.[10] Its effect starts about two hours after intake and lasts for five days.[10]
Common side effects include headache, nausea, easy bruising, itching, and heartburn.[10] More severe side effects include bleeding and thrombotic thrombocytopenic purpura.[10] While there is no evidence of harm from use during pregnancy, such use has not been well studied.[3] Clopidogrel is in the thienopyridine-class of antiplatelets.[10] It works by irreversibly inhibiting a receptor called P2Y12 on platelets.[10]
Clopidogrel was patented in 1982, and approved for medical use in 1997.[6][11] It is on the World Health Organization's List of Essential Medicines.[12] In 2021, it was the 37th most commonly prescribed medication in the United States, with more than 16 million prescriptions.[13][14] It is available as a generic medication.[10]
brands
was invoked but never defined (see the help page).Plavix FDA label
was invoked but never defined (see the help page).© MMXXIII Rich X Search. We shall prevail. All rights reserved. Rich X Search