Colony stimulating factor 1 receptor

CSF1R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2I0V, 2I0Y, 2I1M, 2OGV, 3BEA, 3DPK, 3KRJ, 3KRL, 3LCD, 3LCO, 4DKD, 4HW7, 4LIQ, 4R7H, 4R7I, 4WRL, 4WRM
Identifiers
Aliases	CSF1R, C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R, colony stimulating factor 1 receptor, BANDDOS, HDLS1
External IDs	OMIM: 164770; MGI: 1339758; HomoloGene: 3817; GeneCards: CSF1R; OMA:CSF1R - orthologs
EC number	2.7.10.1
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q32 Start 150,053,291 bp[1] End 150,113,372 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 E1|18 34.41 cM Start 61,233,670 bp[2] End 61,265,221 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte spleen right coronary artery placenta inferior ganglion of vagus nerve retinal pigment epithelium gallbladder appendix lymph node Top expressed in stroma of bone marrow retinal pigment epithelium ankle motor neuron tibiofemoral joint internal carotid artery calvaria substantia nigra gastrula globus pallidus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein tyrosine kinase activity protein kinase activity transferase activity transmembrane receptor protein tyrosine kinase activity kinase activity protein homodimerization activity ATP binding protein phosphatase binding macrophage colony-stimulating factor receptor activity cytokine binding protein binding receptor tyrosine kinase transmembrane signaling receptor activity Cellular component integral component of membrane integral component of plasma membrane membrane cell surface CSF1-CSF1R complex nucleoplasm plasma membrane intracellular membrane-bounded organelle cytoplasm receptor complex Biological process negative regulation of cell population proliferation transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of protein serine/threonine kinase activity mammary gland duct morphogenesis positive regulation of cell motility macrophage colony-stimulating factor signaling pathway phosphatidylinositol-mediated signaling negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade signal transduction axon guidance multicellular organism development monocyte differentiation macrophage differentiation ruffle organization positive regulation of cell migration cellular response to cytokine stimulus protein autophosphorylation peptidyl-tyrosine phosphorylation olfactory bulb development regulation of bone resorption phosphatidylinositol metabolic process protein phosphorylation positive regulation of protein tyrosine kinase activity cell-cell junction maintenance osteoclast differentiation innate immune response regulation of actin cytoskeleton reorganization immune system process inflammatory response positive regulation of protein phosphorylation forebrain neuron differentiation phosphorylation cellular response to macrophage colony-stimulating factor stimulus positive regulation of cell population proliferation regulation of cell shape cell population proliferation positive regulation of tyrosine phosphorylation of STAT protein cytokine-mediated signaling pathway hemopoiesis negative regulation of signal transduction cell differentiation hematopoietic progenitor cell differentiation positive regulation of MAPK cascade response to ischemia microglial cell proliferation positive regulation by host of viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1436 12978 Ensembl ENSG00000182578 ENSMUSG00000024621 UniProt P07333 P09581 RefSeq (mRNA) NM_001288705 NM_005211 NM_001349736 NM_001375320 NM_001375321 NM_001037859 NM_007779 RefSeq (protein) NP_001275634 NP_005202 NP_001336665 NP_001362249 NP_001362250 NP_001032948 Location (UCSC) Chr 5: 150.05 – 150.11 Mb Chr 18: 61.23 – 61.27 Mb PubMed search [3] [4]
Wikidata
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Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded by the human CSF1R gene (known also as c-FMS).^[5][6] CSF1R is a receptor that can be activated by two ligands: colony stimulating factor 1 (CSF-1) and interleukin-34 (IL-34). CSF1R is highly expressed in myeloid cells, and CSF1R signaling is necessary for the survival, proliferation, and differentiation of many myeloid cell types in vivo and in vitro. CSF1R signaling is involved in many diseases and is targeted in therapies for cancer, neurodegeneration, and inflammatory bone diseases.