Cyclin D1

CCND1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2W96, 2W99, 2W9F, 2W9Z
Identifiers
Aliases	CCND1, BCL1, D11S287E, PRAD1, U21B31, cyclin D1
External IDs	OMIM: 168461; MGI: 88313; HomoloGene: 1334; GeneCards: CCND1; OMA:CCND1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	69,654,474 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	144,493,662 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; skin of arm; ; skin of thigh; ; mucosa of paranasal sinus; ; sural nerve; ; gingival epithelium; ; nipple; ; tibia; ; hair follicle; ; skin of abdomen;
	Top expressed in
	calvaria; ; superior cervical ganglion; ; seminal vesicula; ; tail of embryo; ; endothelial cell of lymphatic vessel; ; stroma of bone marrow; ; otic vesicle; ; mandibular prominence; ; genital tubercle; ; human fetus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein kinase activity; transcription corepressor activity; transcription factor binding; histone deacetylase binding; kinase activity; cyclin-dependent protein serine/threonine kinase regulator activity; protein binding; enzyme binding; proline-rich region binding; protein kinase binding; cyclin-dependent protein serine/threonine kinase activity; protein-containing complex binding;
Cellular component	cytoplasm; cytosol; cyclin-dependent protein kinase holoenzyme complex; membrane; bicellular tight junction; transcription repressor complex; intracellular anatomical structure; nucleoplasm; nucleus;
Biological process	cellular response to organic substance; mammary gland epithelial cell proliferation; positive regulation of mammary gland epithelial cell proliferation; response to estradiol; positive regulation of protein phosphorylation; Leydig cell differentiation; regulation of transcription, DNA-templated; response to organic cyclic compound; response to steroid hormone; response to corticosterone; negative regulation of Wnt signaling pathway; response to magnesium ion; response to glucocorticoid; re-entry into mitotic cell cycle; negative regulation of transcription by RNA polymerase II; Wnt signaling pathway; mammary gland alveolus development; response to organic substance; transcription, DNA-templated; response to vitamin E; regulation of cell cycle; response to iron ion; response to estrogen; response to calcium ion; cell division; cellular response to DNA damage stimulus; endoplasmic reticulum unfolded protein response; protein phosphorylation; regulation of G1/S transition of mitotic cell cycle; liver regeneration; mitotic G1 DNA damage checkpoint signaling; animal organ regeneration; response to organonitrogen compound; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; canonical Wnt signaling pathway; response to UV-A; cell cycle; liver development; positive regulation of G2/M transition of mitotic cell cycle; lactation; response to ethanol; response to leptin; negative regulation of epithelial cell differentiation; fat cell differentiation; response to X-ray; positive regulation of cell cycle; transcription initiation from RNA polymerase II promoter; G1/S transition of mitotic cell cycle; cytokine-mediated signaling pathway; positive regulation of epithelial cell proliferation; regulation of cyclin-dependent protein serine/threonine kinase activity; mitotic cell cycle; regulation of mitotic nuclear division; positive regulation of G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	595
	12443
	ENSG00000110092
	ENSMUSG00000070348
	P24385
	P25322
	NM_053056
	NM_007631; NM_001379248
	NP_444284
	NP_031657; NP_001366177
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin D1 is a protein that in humans is encoded by the CCND1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110092 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070348 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Motokura T, Bloom T, Kim HG, Jüppner H, Ruderman JV, Kronenberg HM, Arnold A (April 1991). "A novel cyclin encoded by a bcl1-linked candidate oncogene". Nature. 350 (6318): 512–5. Bibcode:1991Natur.350..512M. doi:10.1038/350512a0. PMID 1826542. S2CID 4232393.
^ Lew DJ, Dulić V, Reed SI (September 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell. 66 (6): 1197–206. doi:10.1016/0092-8674(91)90042-W. PMID 1833066. S2CID 12166415.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110092 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000070348 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1826542-5] Motokura T, Bloom T, Kim HG, Jüppner H, Ruderman JV, Kronenberg HM, Arnold A (April 1991). "A novel cyclin encoded by a bcl1-linked candidate oncogene". Nature. 350 (6318): 512–5. Bibcode:1991Natur.350..512M. doi:10.1038/350512a0. PMID 1826542. S2CID 4232393.

[pmid1833066-6] Lew DJ, Dulić V, Reed SI (September 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell. 66 (6): 1197–206. doi:10.1016/0092-8674(91)90042-W. PMID 1833066. S2CID 12166415.

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