Cytostasis

Cytostasis (cyto – cell; stasis – stoppage) is the inhibition of cell growth and multiplication. Cytostatic refers to a cellular component or medicine that inhibits cell division and induce cell death.^[1]^[2]

Cytostasis is an important prerequisite for structured multicellular organisms. Without regulation of cell growth and division only unorganized heaps of cells would be possible.

Chemotherapy of cancer, treatment of skin diseases and treatment of infections are common use cases of cytostatic drugs; although they can also affect normal and healthy cells and tissues.^[3]^[4] Active hygienic products generally contain cytostatic substances.

Cytostatic mechanisms and drugs generally occur together with cytotoxic ones.

^ Jureczko, Marcelina; Przystaś, Wioletta (2024-07-10). "Toxicity toward freshwater and marine water organisms of the cytostatic drugs bleomycin and vincristine and their binary mixture". Science of the Total Environment. 933: 173175. Bibcode:2024ScTEn.93373175J. doi:10.1016/j.scitotenv.2024.173175. ISSN 0048-9697. PMID 38750736.
^ Gouveia, Teresa I. A.; Alves, Arminda; Santos, Mónica S. F. (2019-12-01). "New insights on cytostatic drug risk assessment in aquatic environments based on measured concentrations in surface waters". Environment International. 133 (Pt B): 105236. Bibcode:2019EnInt.13305236G. doi:10.1016/j.envint.2019.105236. hdl:10216/127536. ISSN 0160-4120. PMID 31675568.
^ Gouveia, Teresa I. A.; Alves, Arminda; Santos, Mónica S. F. (2019-12-01). "New insights on cytostatic drug risk assessment in aquatic environments based on measured concentrations in surface waters". Environment International. 133 (Pt B): 105236. Bibcode:2019EnInt.13305236G. doi:10.1016/j.envint.2019.105236. hdl:10216/127536. ISSN 0160-4120. PMID 31675568.
^ Brezovšek, Polona; Eleršek, Tina; Filipič, Metka (2014-04-01). "Toxicities of four anti-neoplastic drugs and their binary mixtures tested on the green alga Pseudokirchneriella subcapitata and the cyanobacterium Synechococcus leopoliensis". Water Research. 52: 168–177. Bibcode:2014WatRe..52..168B. doi:10.1016/j.watres.2014.01.007. ISSN 0043-1354. PMID 24472702.

[1] Jureczko, Marcelina; Przystaś, Wioletta (2024-07-10). "Toxicity toward freshwater and marine water organisms of the cytostatic drugs bleomycin and vincristine and their binary mixture". Science of the Total Environment. 933: 173175. Bibcode:2024ScTEn.93373175J. doi:10.1016/j.scitotenv.2024.173175. ISSN 0048-9697. PMID 38750736.

[2] Gouveia, Teresa I. A.; Alves, Arminda; Santos, Mónica S. F. (2019-12-01). "New insights on cytostatic drug risk assessment in aquatic environments based on measured concentrations in surface waters". Environment International. 133 (Pt B): 105236. Bibcode:2019EnInt.13305236G. doi:10.1016/j.envint.2019.105236. hdl:10216/127536. ISSN 0160-4120. PMID 31675568.

[3] Gouveia, Teresa I. A.; Alves, Arminda; Santos, Mónica S. F. (2019-12-01). "New insights on cytostatic drug risk assessment in aquatic environments based on measured concentrations in surface waters". Environment International. 133 (Pt B): 105236. Bibcode:2019EnInt.13305236G. doi:10.1016/j.envint.2019.105236. hdl:10216/127536. ISSN 0160-4120. PMID 31675568.

[4] Brezovšek, Polona; Eleršek, Tina; Filipič, Metka (2014-04-01). "Toxicities of four anti-neoplastic drugs and their binary mixtures tested on the green alga Pseudokirchneriella subcapitata and the cyanobacterium Synechococcus leopoliensis". Water Research. 52: 168–177. Bibcode:2014WatRe..52..168B. doi:10.1016/j.watres.2014.01.007. ISSN 0043-1354. PMID 24472702.

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