DC-SIGN

CD209
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1K9I, 1SL4, 1SL5, 2B6B, 2IT5, 2IT6, 2XR5, 2XR6
Identifiers
Aliases	CD209, CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, CD209 molecule, hDC-SIGN
External IDs	OMIM: 604672; MGI: 2157948; HomoloGene: 128353; GeneCards: CD209; OMA:CD209 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	7,747,564 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	3,904,309 bp
RNA expression pattern
	Top expressed in
	lymph node; ; superficial temporal artery; ; decidua; ; rectum; ; right coronary artery; ; mucosa of ileum; ; jejunal mucosa; ; gallbladder; ; apex of heart; ; duodenum;
	Top expressed in
	morula; ; skin of abdomen; ; blastocyst; ; mesenteric lymph nodes; ; lip; ; skin of external ear; ; thymus; ; muscle of thigh; ; skin of back; ; white adipose tissue;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptide antigen binding; virus receptor activity; metal ion binding; protein binding; mannose binding; virion binding; carbohydrate binding;
Cellular component	cytoplasm; integral component of membrane; membrane; extracellular region; cell surface; extracellular exosome; external side of plasma membrane; host cell; plasma membrane;
Biological process	leukocyte cell-cell adhesion; cell-cell recognition; intracellular transport of virus; regulation of T cell proliferation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; intracellular signal transduction; antigen processing and presentation; endocytosis; adaptive immune response; immune system process; viral genome replication; stimulatory C-type lectin receptor signaling pathway; peptide antigen transport; cell adhesion; modulation by virus of host process; viral entry into host cell; viral process; virion attachment to host cell; innate immune response; positive regulation of T cell proliferation; B cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	30835
	170780
	ENSG00000090659
	ENSMUSG00000040197
	Q9NNX6
	Q91ZW7
NM_001144893; NM_001144894; NM_001144895; NM_001144896; NM_001144897;
	NM_001144899; NM_021155
	NM_130905
NP_001138365; NP_001138366; NP_001138367; NP_001138368; NP_001138369;
	NP_001138371; NP_066978
	NP_570975
	Wikidata
View/Edit Human	View/Edit Mouse

DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209 (Cluster of Differentiation 209) is a protein which in humans is encoded by the CD209 gene.^[5]

DC-SIGN is a C-type lectin receptor present on the surface of both macrophages and dendritic cells. DC-SIGN on macrophages recognises and binds with high affinity to high-mannose type N-glycans, a class of PAMPs (pathogen associated molecular patterns) commonly found on viruses, bacteria and fungi. This binding interaction activates phagocytosis.^[6] On myeloid and pre-plasmacytoid dendritic cells DC-SIGN mediates dendritic cell rolling interactions with blood endothelium and activation of CD4+ T cells, as well as recognition of pathogen haptens.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000090659 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040197 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Curtis BM, Scharnowske S, Watson AJ (September 1992). "Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120". Proceedings of the National Academy of Sciences of the United States of America. 89 (17): 8356–8360. Bibcode:1992PNAS...89.8356C. doi:10.1073/pnas.89.17.8356. PMC 49917. PMID 1518869.
^ McGreal EP, Miller JL, Gordon S (February 2005). "Ligand recognition by antigen-presenting cell C-type lectin receptors". Current Opinion in Immunology. 17 (1): 18–24. doi:10.1016/j.coi.2004.12.001. PMC 7126011. PMID 15653305.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000090659 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040197 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1518869-5] Curtis BM, Scharnowske S, Watson AJ (September 1992). "Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120". Proceedings of the National Academy of Sciences of the United States of America. 89 (17): 8356–8360. Bibcode:1992PNAS...89.8356C. doi:10.1073/pnas.89.17.8356. PMC 49917. PMID 1518869.

[6] McGreal EP, Miller JL, Gordon S (February 2005). "Ligand recognition by antigen-presenting cell C-type lectin receptors". Current Opinion in Immunology. 17 (1): 18–24. doi:10.1016/j.coi.2004.12.001. PMC 7126011. PMID 15653305.

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