Death receptor 4

TNFRSF10A
Identifiers
Aliases	TNFRSF10A, APO2, CD261, DR4, TRAILR-1, TRAILR1, tumor necrosis factor receptor superfamily member 10a, TNF receptor superfamily member 10a
External IDs	OMIM: 603611; MGI: 1341090; HomoloGene: 129806; GeneCards: TNFRSF10A; OMA:TNFRSF10A - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	23,225,102 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	70,021,860 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; nipple; ; pancreatic ductal cell; ; tendon of biceps brachii; ; pylorus; ; lymph node; ; superficial temporal artery; ; epithelium of colon; ; mucosa of pharynx; ; nasal epithelium;
	Top expressed in
	urethra; ; female urethra; ; male urethra; ; genital tubercle; ; morula; ; endothelial cell of lymphatic vessel; ; tail of embryo; ; lens; ; embryo; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	TRAIL binding; transcription factor binding; protease binding; protein binding; tumor necrosis factor-activated receptor activity; death receptor activity; signaling receptor activity;
Cellular component	membrane; plasma membrane; integral component of plasma membrane; cell surface; intracellular anatomical structure; integral component of membrane;
Biological process	activation of NF-kappaB-inducing kinase activity; TRAIL-activated apoptotic signaling pathway; multicellular organism development; cell surface receptor signaling pathway; response to lipopolysaccharide; cellular response to mechanical stimulus; regulation of cell population proliferation; immune response; regulation of extrinsic apoptotic signaling pathway via death domain receptors; inflammatory response; activation of cysteine-type endopeptidase activity involved in apoptotic process; extrinsic apoptotic signaling pathway via death domain receptors; signal transduction; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; extrinsic apoptotic signaling pathway; tumor necrosis factor-mediated signaling pathway; apoptotic process; leukocyte migration; regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	8797
	21933
	ENSG00000104689
	ENSMUSG00000022074
	O00220
	Q9QZM4
	NM_003844
	NM_020275
	NP_003835
	NP_064671
	Wikidata
View/Edit Human	View/Edit Mouse

Death receptor 4 (DR4), also known as TRAIL receptor 1 (TRAILR1) and tumor necrosis factor receptor superfamily member 10A (TNFRSF10A), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104689 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022074 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Walczak H, Degli-Esposti MA, Johnson RS, Smolak PJ, Waugh JY, Boiani N, Timour MS, Gerhart MJ, Schooley KA, Smith CA, Goodwin RG, Rauch CT (Dec 1997). "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL". EMBO J. 16 (17): 5386–97. doi:10.1093/emboj/16.17.5386. PMC 1170170. PMID 9311998.
^ Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM (April 1997). "The receptor for the cytotoxic ligand TRAIL". Science. 276 (5309): 111–3. doi:10.1126/science.276.5309.111. PMID 9082980. S2CID 19984057.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104689 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022074 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9311998-5] Walczak H, Degli-Esposti MA, Johnson RS, Smolak PJ, Waugh JY, Boiani N, Timour MS, Gerhart MJ, Schooley KA, Smith CA, Goodwin RG, Rauch CT (Dec 1997). "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL". EMBO J. 16 (17): 5386–97. doi:10.1093/emboj/16.17.5386. PMC 1170170. PMID 9311998.

[pmid9082980-6] Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM (April 1997). "The receptor for the cytotoxic ligand TRAIL". Science. 276 (5309): 111–3. doi:10.1126/science.276.5309.111. PMID 9082980. S2CID 19984057.

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