Death receptor 6

TNFRSF21
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3QO4, 3U3P, 3U3Q, 3U3S, 3U3T, 3U3V, 2DBH
Identifiers
Aliases	TNFRSF21, BM-018, CD358, DR6, tumor necrosis factor receptor superfamily member 21, TNF receptor superfamily member 21
External IDs	OMIM: 605732; MGI: 2151075; HomoloGene: 8696; GeneCards: TNFRSF21; OMA:TNFRSF21 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	47,309,905 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	43,400,080 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; mucosa of urinary bladder; ; periodontal fiber; ; subthalamic nucleus; ; epithelium of nasopharynx; ; inferior ganglion of vagus nerve; ; pons; ; lateral nuclear group of thalamus; ; beta cell; ; pars reticulata;
	Top expressed in
	right kidney; ; epithelium of stomach; ; decidua; ; pyloric antrum; ; proximal tubule; ; mucous cell of stomach; ; human kidney; ; facial motor nucleus; ; granulocyte; ; anterior horn of spinal cord;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	tumor necrosis factor-activated receptor activity;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; axon; plasma membrane; intrinsic component of plasma membrane; cytoplasm;
Biological process	regulation of apoptotic process; immune system process; cellular response to tumor necrosis factor; response to lipopolysaccharide; regulation of cell population proliferation; immune response; apoptotic signaling pathway; inflammatory response; negative regulation of myelination; signal transduction; apoptotic process; oligodendrocyte apoptotic process; negative regulation of B cell proliferation; neuron apoptotic process; humoral immune response; myelination; negative regulation of T cell proliferation; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; B cell apoptotic process; adaptive immune response; regulation of oligodendrocyte differentiation; regulation of lipid metabolic process; axonal fasciculation;
	Sources:Amigo / QuickGO
Orthologs
	27242
	94185
	ENSG00000146072
	ENSMUSG00000023915
	O75509
	Q9EPU5
	NM_014452
	NM_178589
	NP_055267
	NP_848704
	Wikidata
View/Edit Human	View/Edit Mouse

Death receptor 6 (DR6), also known as tumor necrosis factor receptor superfamily member 21 (TNFRSF21), is a cell surface receptor of the tumor necrosis factor receptor superfamily which activates the JNK and NF-κB pathways.^[5]^[6] It is mostly expressed in the thymus, spleen and white blood cells.^[7] The Gene for DR6 is 78,450 bases long and is found on the 6th chromosome. This is transcribed into a 655 amino acid chain weighing 71.8 kDa. Post transcriptional modifications of this protein include glycosylation on the asparagines at the 82, 141, 252, 257, 278, and 289 amino acid locations.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000146072 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023915 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM (July 1998). "Identification and functional characterization of DR6, a novel death domain-containing TNF receptor" (PDF). FEBS Letters. 431 (3): 351–6. doi:10.1016/S0014-5793(98)00791-1. hdl:2027.42/116991. PMID 9714541. S2CID 11151198.
^ "Entrez Gene: TNFRSF21 tumor necrosis factor receptor superfamily, member 21".
^ Salido GM, Rosado JA (2009). Apoptosis: Involvement of Oxidative Stress and Intracellular Ca2+ Homeostasis. Heidelberg, Germany: Springer. p. 37. ISBN 9781402098734.
^ Cite error: The named reference Mungall_2003 was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000146072 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023915 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9714541-5] Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM (July 1998). "Identification and functional characterization of DR6, a novel death domain-containing TNF receptor" (PDF). FEBS Letters. 431 (3): 351–6. doi:10.1016/S0014-5793(98)00791-1. hdl:2027.42/116991. PMID 9714541. S2CID 11151198.

[entrez-6] "Entrez Gene: TNFRSF21 tumor necrosis factor receptor superfamily, member 21".

[7] Salido GM, Rosado JA (2009). Apoptosis: Involvement of Oxidative Stress and Intracellular Ca2+ Homeostasis. Heidelberg, Germany: Springer. p. 37. ISBN 9781402098734.

[Mungall_2003-8] Cite error: The named reference Mungall_2003 was invoked but never defined (see the help page).

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]