Decoy receptor 3

TNFRSF6B
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3K51, 3MHD, 3MI8, 4J6G, 4KGG, 4KGQ, 4MSV
Identifiers
Aliases	TNFRSF6B, DCR3, DJ583P15.1.1, M68, M68E, TR6, tumor necrosis factor receptor superfamily member 6b, TNF receptor superfamily member 6b
External IDs	OMIM: 603361; HomoloGene: 48242; GeneCards: TNFRSF6B; OMA:TNFRSF6B - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	63,698,684 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; spleen; ; subcutaneous adipose tissue; ; right lung; ; upper lobe of left lung; ; C1 segment; ; right hemisphere of cerebellum; ; appendix; ; anterior pituitary; ; amygdala;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; tumor necrosis factor-activated receptor activity; signaling receptor activity;
Cellular component	extracellular region; integral component of plasma membrane; extracellular space;
Biological process	multicellular organism development; apoptotic signaling pathway; response to lipopolysaccharide; inflammatory response; tumor necrosis factor-mediated signaling pathway; negative regulation of apoptotic process; regulation of cell population proliferation; immune response; apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	8771
	n/a
	ENSG00000243509
	n/a
	O95407
	n/a
	NM_032945; NM_003823
	n/a
	NP_003814
	n/a
	Wikidata
View/Edit Human

Decoy receptor 3 (Dcr3), also known as tumor necrosis factor receptor superfamily member 6B (TNFRSF6B), TR6 and M68, is a soluble protein of the tumor necrosis factor receptor superfamily which inhibits Fas ligand-induced apoptosis.^[3]^[4]^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000243509 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pitti RM, Marsters SA, Lawrence DA, Roy M, Kischkel FC, Dowd P, Huang A, Donahue CJ, Sherwood SW, Baldwin DT, Godowski PJ, Wood WI, Gurney AL, Hillan KJ, Cohen RL, Goddard AD, Botstein D, Ashkenazi A (Jan 1999). "Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer". Nature. 396 (6712): 699–703. doi:10.1038/25387. PMID 9872321. S2CID 4427455.
^ Yu KY, Kwon B, Ni J, Zhai Y, Ebner R, Kwon BS (Jun 1999). "A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis". J Biol Chem. 274 (20): 13733–6. doi:10.1074/jbc.274.20.13733. PMID 10318773.
^ "Entrez Gene: TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000243509 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9872321-3] Pitti RM, Marsters SA, Lawrence DA, Roy M, Kischkel FC, Dowd P, Huang A, Donahue CJ, Sherwood SW, Baldwin DT, Godowski PJ, Wood WI, Gurney AL, Hillan KJ, Cohen RL, Goddard AD, Botstein D, Ashkenazi A (Jan 1999). "Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer". Nature. 396 (6712): 699–703. doi:10.1038/25387. PMID 9872321. S2CID 4427455.

[pmid10318773-4] Yu KY, Kwon B, Ni J, Zhai Y, Ebner R, Kwon BS (Jun 1999). "A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis". J Biol Chem. 274 (20): 13733–6. doi:10.1074/jbc.274.20.13733. PMID 10318773.

[entrez-5] "Entrez Gene: TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy".

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