Dermatopontin

DPT
Identifiers
Aliases	DPT, TRAMP, dermatopontin
External IDs	OMIM: 125597; MGI: 1928392; HomoloGene: 1458; GeneCards: DPT; OMA:DPT - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	168,729,206 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	164,651,835 bp
RNA expression pattern
	Top expressed in
	smooth muscle tissue; ; muscle layer of sigmoid colon; ; epithelium of colon; ; right auricle; ; subcutaneous adipose tissue; ; lactiferous gland; ; left uterine tube; ; gallbladder; ; gastric mucosa; ; fundus;
	Top expressed in
	semi-lunar valve; ; aortic valve; ; cervix; ; subcutaneous adipose tissue; ; intercostal muscle; ; skin of abdomen; ; carotid body; ; ankle; ; ascending aorta; ; white adipose tissue;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	extracellular matrix structural constituent; protein binding;
Cellular component	extracellular matrix; extracellular region; extracellular exosome; extracellular space; collagen-containing extracellular matrix;
Biological process	cell adhesion; negative regulation of cell population proliferation; collagen fibril organization;
	Sources:Amigo / QuickGO
Orthologs
	1805
	56429
	ENSG00000143196
	ENSMUSG00000026574
	Q07507
	Q9QZZ6
	NM_001937
	NM_019759
	NP_001928
	NP_062733
	Wikidata
View/Edit Human	View/Edit Mouse

Dermatopontin also known as tyrosine-rich acidic matrix protein (TRAMP) is a protein that in humans is encoded by the DPT gene.^[5]^[6] Dermatopontin is a 22-kDa protein of the noncollagenous extracellular matrix (ECM) estimated to comprise 12 mg/kg of wet dermis weight.^[7] To date, homologues have been identified in five different mammals and 12 different invertebrates with multiple functions.^[8] In vertebrates, the primary function of dermatopontin is a structural component of the ECM (interaction with decorin and modification of collagen fibrillogenesis), cell adhesion, modulation of TGF-β activity and cellular quiescence). It also has pathological involvement in heart attacks (increased expression around myocardial infarct zone) and decreased expression in leiomyoma and fibrosis. In invertebrate, dermatopontin homologue plays a role in hemagglutination, cell-cell aggregation, and expression during parasite infection.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143196 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026574 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Superti-Furga A, Rocchi M, Schäfer BW, Gitzelmann R (August 1993). "Complementary DNA sequence and chromosomal mapping of a human proteoglycan-binding cell-adhesion protein (dermatopontin)". Genomics. 17 (2): 463–7. doi:10.1006/geno.1993.1348. PMID 8104875.
^ "Entrez Gene: DPT dermatopontin".
^ Krishnaswamy VR, Korrapati PS (December 2014). "Role of dermatopontin in re-epithelialization: implications on keratinocyte migration and proliferation". Scientific Reports. 4: 7385. Bibcode:2014NatSR...4E7385K. doi:10.1038/srep07385. PMC 4260223. PMID 25486882.
^ ^a ^b Okamoto O, Fujiwara S (2006). "Dermatopontin, a novel player in the biology of the extracellular matrix". Connective Tissue Research. 47 (4): 177–89. doi:10.1080/03008200600846564. PMID 16987749. S2CID 23944137.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143196 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026574 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8104875-5] Superti-Furga A, Rocchi M, Schäfer BW, Gitzelmann R (August 1993). "Complementary DNA sequence and chromosomal mapping of a human proteoglycan-binding cell-adhesion protein (dermatopontin)". Genomics. 17 (2): 463–7. doi:10.1006/geno.1993.1348. PMID 8104875.

[entrez-6] "Entrez Gene: DPT dermatopontin".

[Krishnaswamy_2014-7] Krishnaswamy VR, Korrapati PS (December 2014). "Role of dermatopontin in re-epithelialization: implications on keratinocyte migration and proliferation". Scientific Reports. 4: 7385. Bibcode:2014NatSR...4E7385K. doi:10.1038/srep07385. PMC 4260223. PMID 25486882.

[Okamoto_2006-8] Okamoto O, Fujiwara S (2006). "Dermatopontin, a novel player in the biology of the extracellular matrix". Connective Tissue Research. 47 (4): 177–89. doi:10.1080/03008200600846564. PMID 16987749. S2CID 23944137.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]