Desmosine

Desmosine
Names
	IUPAC name 6-{4-[(4S)-4-Amino-4-carboxybutyl]-3,5-bis[(3S)-3-amino-3-carboxypropyl]-1-pyridiniumyl}-L-norleucine
Identifiers
CAS Number	11003-57-9 ;
3D model (JSmol)	Interactive image;
Beilstein Reference	4074277
ChEBI	CHEBI:37628;
ChemSpider	13085543 ;
PubChem CID	25435;
UNII	4MOL2J0TLY ;
CompTox Dashboard (EPA)	DTXSID801106522 ;
	InChI InChI=1S/C24H39N5O8/c25-17(21(30)31)5-1-2-11-29-12-14(7-9-19(27)23(34)35)16(4-3-6-18(26)22(32)33)15(13-29)8-10-20(28)24(36)37/h12-13,17-20H,1-11,25-28H2,(H3-,30,31,32,33,34,35,36,37)/p+1 Key: VEVRNHHLCPGNDU-MUGJNUQGSA-O ;
	SMILES O=C(O)[C@@H](N)CCCC[n+]1cc(c(c(c1)CC[C@@H](C(=O)O)N)CCC[C@@H](C(=O)O)N)CC[C@@H](C(=O)O)N;
Properties
Chemical formula	C24H40N5O8
Molar mass	526.611 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Desmosine is an amino acid found uniquely in elastin, a protein found in connective tissue such as skin, lungs, and elastic arteries.

Desmosine is a component of elastin and cross links with its isomer, isodesmosine, giving elasticity to the tissue. Detection of desmosine in urine, plasma or sputum samples can be a marker for elastin breakdown due to high elastase activity related to certain diseases.^[1]^[2]

^ Millipore product catalogue, purified desmosine "Desmosine - Millipore". Archived from the original on 2014-02-24. Retrieved 2014-02-19.
^ Ma, S; Turino, G. M.; Lin, Y. Y. (2011). "Quantitation of desmosine and isodesmosine in urine, plasma, and sputum by LC-MS/MS as biomarkers for elastin degradation". Journal of Chromatography B. 879 (21): 1893–8. doi:10.1016/j.jchromb.2011.05.011. PMID 21621489.

[1] Millipore product catalogue, purified desmosine "Desmosine - Millipore". Archived from the original on 2014-02-24. Retrieved 2014-02-19.

[2] Ma, S; Turino, G. M.; Lin, Y. Y. (2011). "Quantitation of desmosine and isodesmosine in urine, plasma, and sputum by LC-MS/MS as biomarkers for elastin degradation". Journal of Chromatography B. 879 (21): 1893–8. doi:10.1016/j.jchromb.2011.05.011. PMID 21621489.

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