Dopamine receptor D2

DRD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 6CM4
Identifiers
Aliases	DRD2, D2DR, D2R, dopamine receptor D2
External IDs	OMIM: 126450; MGI: 94924; HomoloGene: 22561; GeneCards: DRD2; OMA:DRD2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.2 Start 113,409,605 bp[1] End 113,475,691 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.3|9 26.72 cM Start 49,251,927 bp[2] End 49,319,477 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in putamen nucleus accumbens testicle pituitary gland caudate nucleus anterior pituitary triceps brachii muscle Pars compacta pars reticulata ventral tegmental area Top expressed in superior frontal gyrus striatum of neuraxis dorsal striatum nucleus accumbens olfactory epithelium lumbar subsegment of spinal cord neural layer of retina olfactory tubercle embryo ankle joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity potassium channel regulator activity dopamine neurotransmitter receptor activity, coupled via Gi/Go identical protein binding dopamine neurotransmitter receptor activity G protein-coupled receptor activity protein binding signal transducer activity adrenergic receptor activity dopamine binding signaling receptor binding ionotropic glutamate receptor binding protein heterodimerization activity Cellular component cytoplasmic vesicle sperm flagellum endocytic vesicle acrosomal vesicle dendritic spine synaptic vesicle membrane perikaryon plasma membrane dendrite ciliary membrane axon terminus integral component of membrane postsynaptic density membrane lateral plasma membrane axon intracellular anatomical structure non-motile cilium integral component of plasma membrane dopaminergic synapse glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane Biological process negative regulation of cell population proliferation temperature homeostasis adenylate cyclase-inhibiting dopamine receptor signaling pathway adenohypophysis development circadian regulation of gene expression response to toxic substance regulation of dopamine secretion response to cocaine response to amphetamine sensory perception of smell locomotory behavior positive regulation of urine volume response to ethanol axonogenesis response to inactivity phospholipase C-activating dopamine receptor signaling pathway modulation of chemical synaptic transmission grooming behavior negative regulation of protein kinase B signaling associative learning positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway regulation of dopamine uptake involved in synaptic transmission regulation of synaptic transmission, GABAergic positive regulation of dopamine uptake involved in synaptic transmission signal transduction Wnt signaling pathway adult walking behavior branching morphogenesis of a nerve negative regulation of cytosolic calcium ion concentration negative regulation of innate immune response regulation of phosphoprotein phosphatase activity acid secretion feeding behavior positive regulation of G protein-coupled receptor signaling pathway response to axon injury striatum development synaptic transmission, dopaminergic nervous system process involved in regulation of systemic arterial blood pressure peristalsis regulation of long-term neuronal synaptic plasticity activation of protein kinase activity positive regulation of growth hormone secretion regulation of sodium ion transport forebrain development response to light stimulus orbitofrontal cortex development prepulse inhibition response to morphine response to iron ion positive regulation of ERK1 and ERK2 cascade long-term memory positive regulation of renal sodium excretion negative regulation of insulin secretion neuron-neuron synaptic transmission intracellular signal transduction auditory behavior behavioral response to ethanol regulation of heart rate adenylate cyclase-activating adrenergic receptor signaling pathway positive regulation of cytokinesis regulation of potassium ion transport pigmentation cellular calcium ion homeostasis dopamine metabolic process response to nicotine regulation of MAPK cascade response to histamine negative regulation of synaptic transmission, glutamatergic response to hypoxia negative regulation of circadian sleep/wake cycle, sleep negative regulation of protein secretion synapse assembly regulation of locomotion involved in locomotory behavior dopamine receptor signaling pathway negative regulation of dopamine receptor signaling pathway startle response positive regulation of receptor internalization protein localization arachidonic acid secretion positive regulation of transcription by RNA polymerase II G protein-coupled receptor internalization positive regulation of multicellular organism growth positive regulation of long-term synaptic potentiation negative regulation of dopamine secretion adult behavior cerebral cortex GABAergic interneuron migration regulation of synapse structural plasticity adenylate cyclase-modulating G protein-coupled receptor signaling pathway visual learning negative regulation of cell migration behavioral response to cocaine positive regulation of neuroblast proliferation negative regulation of blood pressure release of sequestered calcium ion into cytosol negative regulation of voltage-gated calcium channel activity G protein-coupled receptor signaling pathway negative regulation of adenylate cyclase activity excitatory postsynaptic potential negative regulation of protein phosphorylation autophagy positive regulation of neurogenesis negative regulation of cell death drinking behavior adrenergic receptor signaling pathway regulation of neurotransmitter uptake postsynaptic modulation of chemical synaptic transmission regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1813 13489 Ensembl ENSG00000149295 ENSMUSG00000032259 UniProt P14416 P61168 RefSeq (mRNA) NM_016574 NM_000795 NM_010077 RefSeq (protein) NP_000786 NP_057658 NP_000786.1 NP_034207 Location (UCSC) Chr 11: 113.41 – 113.48 Mb Chr 9: 49.25 – 49.32 Mb PubMed search [3] [4]
Wikidata
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Dopamine receptor D₂, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene. After work from Paul Greengard's lab had suggested that dopamine receptors were the site of action of antipsychotic drugs, several groups, including those of Solomon H. Snyder and Philip Seeman used a radiolabeled antipsychotic drug to identify what is now known as the dopamine D₂ receptor.^[5] The dopamine D₂ receptor is the main receptor for most antipsychotic drugs. The structure of DRD2 in complex with the atypical antipsychotic risperidone has been determined.^[6][7]