Dopamine receptor D5

DRD5
Identifiers
Aliases	DRD5, DBDR, DRD1B, DRD1L2, dopamine receptor D5
External IDs	OMIM: 126453; MGI: 94927; HomoloGene: 20216; GeneCards: DRD5; OMA:DRD5 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.1 Start 9,781,634 bp[1] End 9,784,009 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 B3|5 20.4 cM Start 38,476,710 bp[2] End 38,479,861 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell tibialis anterior muscle mucosa of ileum prefrontal cortex anterior cingulate cortex deltoid muscle Brodmann area 9 appendix hypothalamus skin of thigh Top expressed in trigeminal ganglion hippocampus proper spinal ganglia vasculature dentate gyrus of hippocampal formation granule cell embryo vasculature of organ embryo ganglion of vagus nerve glossopharyngeal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity dopamine neurotransmitter receptor activity signal transducer activity dopamine binding dopamine neurotransmitter receptor activity, coupled via Gs G-protein alpha-subunit binding Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane brush border membrane ciliary membrane non-motile cilium intracellular anatomical structure cilium Biological process response to cocaine cellular response to catecholamine stimulus regulation of female receptivity sensitization adenylate cyclase-activating dopamine receptor signaling pathway associative learning adenylate cyclase-activating G protein-coupled receptor signaling pathway norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure negative regulation of blood pressure transmission of nerve impulse response to amphetamine regulation of systemic arterial blood pressure by vasopressin wound healing cellular calcium ion homeostasis mating behavior learning negative regulation of NAD(P)H oxidase activity activation of adenylate cyclase activity reactive oxygen species metabolic process phospholipase C-activating dopamine receptor signaling pathway long-term depression signal transduction chemical synaptic transmission synaptic transmission, dopaminergic G protein-coupled receptor signaling pathway positive regulation of adenylate cyclase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1816 13492 Ensembl ENSG00000169676 ENSMUSG00000039358 UniProt P21918 Q8BLD9 RefSeq (mRNA) NM_000798 NM_013503 RefSeq (protein) NP_000789 NP_038531 Location (UCSC) Chr 4: 9.78 – 9.78 Mb Chr 5: 38.48 – 38.48 Mb PubMed search [3] [4]
Wikidata
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Dopamine receptor D₅, also known as D1BR, is a protein that in humans is encoded by the DRD5 gene.^[5] It belongs to the D₁-like receptor family along with the D₁ receptor subtype.