Doramectin

Doramectin
Clinical data
Trade names	Dectomax, others
Other names	25-cyclohexylavermectin B1,; 25-cyclohexyl-25-de(l-methylpropyl)avermectin B1a,; 25-cyclohexyl-5-O-demethyl-25-de(l-methylpropyl)avermectin A1a;
AHFS/Drugs.com	International Drug Names
License data	US DailyMed: Doramectin;
Routes of; administration	Subcutaneous, intramuscular, topical
ATCvet code	QP54AA03 (WHO) ;
Legal status
Legal status	US: OTC for animals;
Identifiers
	IUPAC name (1'R,2S,4'S,5S,6R,8'R,10'E,12'R,13'S,14'E,20'R,21'R,24'S)-6-cyclohexyl-21',24'-dihydroxy-12'-{[(2R,4S,5S,6S)-5-{[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-5,6-dihydro-3',7',19'-trioxaspiro[pyran-2,6'-tetracyclo[15.6.1.14,8.020,24]pentacosane]-10',14',16',22'-tetraen-2'-one;
CAS Number	117704-25-3 ;
PubChem CID	9832750;
ChemSpider	8008478 ;
UNII	KGD7A54H5P;
KEGG	D01129 ;
CompTox Dashboard (EPA)	DTXSID9048982 ;
ECHA InfoCard	100.123.125
Chemical and physical data
Formula	C50H74O14
Molar mass	899.128 g·mol−1
	InChI InChI=1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46-,47+,49+,50+/m0/s1 ; Key:QLFZZSKTJWDQOS-YDBLARSUSA-N ;
	(verify)

Doramectin, sold under the brand name Dectomax among others, is a veterinary medication approved by the US Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice, and mange mites in cattle.^[1]^[2] It is available as a generic medication.^[3] It is available as a combination with levamisole under the brand name Valcor.^[4]

It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is a derivative of avermectin. Similarly to other drugs of this family, it is produced by fermentation by selected strains of Streptomyces avermitilis followed by chemical modification.^[1]^[2]^[5] Its spectrum includes: Haemonchus, Ostertagia, Trichostrongylus, Cooperia, and Oesophagostomum species and Dictyocaulus viviparus, Dermatobia hominis, Boophilus microplus, and Psoroptes bovis, among many other internal and external parasites. It is available as an injection and as a topical solution.^[1]^[2]

^ ^a ^b ^c ^d "Dectomax- doramectin injection, solution". DailyMed. 13 September 2022. Retrieved 25 January 2023.
^ ^a ^b ^c ^d "Dectomax Pour-On- doramectin solution". DailyMed. 5 August 2022. Retrieved 25 January 2023.
^ ^a ^b "FDA Approves First Generic Doramectin for Use in Cattle". U.S. Food and Drug Administration (FDA). 11 January 2023. Retrieved 25 January 2023.
^ "Animal Drugs @ FDA". animaldrugsatfda.fda.gov. Retrieved 25 January 2023.
^ Goudie AC, Evans NA, Gration KA, Bishop BF, Gibson SP, Holdom KS, et al. (July 1993). "Doramectin--a potent novel endectocide". Veterinary Parasitology. 49 (1): 5–15. doi:10.1016/0304-4017(93)90218-c. PMID 8236738.