EMR2

ADGRE2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2BOX, 2BO2, 2BOU
Identifiers
Aliases	ADGRE2, CD312, VBU, EMR2, adhesion G protein-coupled receptor E2, CD97
External IDs	OMIM: 606100; HomoloGene: 113735; GeneCards: ADGRE2; OMA:ADGRE2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	14,778,560 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; spleen; ; appendix; ; periodontal fiber; ; upper lobe of left lung; ; palpebral conjunctiva; ; right lung; ; gallbladder;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; chondroitin sulfate binding; transmembrane signaling receptor activity; signal transducer activity; G protein-coupled receptor activity;
Cellular component	ruffle membrane; plasma membrane; cell projection; membrane; leading edge membrane; integral component of membrane; intracellular anatomical structure; integral component of plasma membrane;
Biological process	cell surface receptor signaling pathway; inflammatory response; cell migration; granulocyte chemotaxis; signal transduction; G protein-coupled receptor signaling pathway; cell adhesion; regulation of mast cell degranulation; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	30817
	n/a
	ENSG00000127507
	n/a
	Q9UHX3
	n/a
NM_001271052; NM_013447; NM_152916; NM_152917; NM_152918;
	NM_152919; NM_152920; NM_152921
	n/a
	NP_001257981; NP_038475
	n/a
	Wikidata
View/Edit Human

EGF-like module-containing mucin-like hormone receptor-like 2 also known as CD312 (cluster of differentiation 312) is a protein encoded by the ADGRE2 gene.^[3] EMR2 is a member of the adhesion GPCR family.^[4]^[5] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[6]

EMR2 is expressed by monocytes/macrophages, dendritic cells and all types of granulocytes.^[7] In the case of EMR2 the N-terminal domains consist of alternatively spliced epidermal growth factor-like (EGF-like) domains. EMR2 is closely related to CD97 with 97% amino-acid identity in the EGF-like domains. The N-terminal fragment (NTF) of EMR2 presents 2-5 EGF-like domains in human.^[8] Mice lack the Emr2 gene.^[9] This gene is closely linked to the gene encoding EGF-like molecule containing mucin-like hormone receptor 3 EMR3 on chromosome 19.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127507 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
^ Langenhan T, Aust G, Hamann J (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.
^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
^ Lin HH, Stacey M, Hamann J, Gordon S, McKnight AJ (July 2000). "Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97". Genomics. 67 (2): 188–200. doi:10.1006/geno.2000.6238. PMID 10903844.
^ Gordon S, Hamann J, Lin HH, Stacey M (September 2011). "F4/80 and the related adhesion-GPCRs". European Journal of Immunology. 41 (9): 2472–6. doi:10.1002/eji.201141715. PMID 21952799. S2CID 29257475.
^ Kwakkenbos MJ, Matmati M, Madsen O, Pouwels W, Wang Y, Bontrop RE, Heidt PJ, Hoek RM, Hamann J (December 2006). "An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2". FASEB Journal. 20 (14): 2582–4. doi:10.1096/fj.06-6500fje. PMID 17068111. S2CID 16254868.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127507 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.

[isbn1-4419-7912-3-4] Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.

[5] Langenhan T, Aust G, Hamann J (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.

[pmid22333914-6] Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

[7] Lin HH, Stacey M, Hamann J, Gordon S, McKnight AJ (July 2000). "Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97". Genomics. 67 (2): 188–200. doi:10.1006/geno.2000.6238. PMID 10903844.

[8] Gordon S, Hamann J, Lin HH, Stacey M (September 2011). "F4/80 and the related adhesion-GPCRs". European Journal of Immunology. 41 (9): 2472–6. doi:10.1002/eji.201141715. PMID 21952799. S2CID 29257475.

[9] Kwakkenbos MJ, Matmati M, Madsen O, Pouwels W, Wang Y, Bontrop RE, Heidt PJ, Hoek RM, Hamann J (December 2006). "An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2". FASEB Journal. 20 (14): 2582–4. doi:10.1096/fj.06-6500fje. PMID 17068111. S2CID 16254868.

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