ENPP3

ENPP3
Identifiers
Aliases	ENPP3, B10, CD203c, NPP3, PD-IBETA, PDNP3, ectonucleotide pyrophosphatase/phosphodiesterase 3
External IDs	OMIM: 602182; MGI: 2143702; HomoloGene: 3683; GeneCards: ENPP3; OMA:ENPP3 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	131,747,418 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	24,718,721 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of ileum; ; seminal vesicula; ; duodenum; ; mucosa of paranasal sinus; ; bronchial epithelial cell; ; endometrium; ; buccal mucosa cell; ; tibialis anterior muscle; ; olfactory zone of nasal mucosa;
	Top expressed in
	epithelium of small intestine; ; conjunctival fornix; ; intestinal villus; ; duodenum; ; parotid gland; ; lacrimal gland; ; cornea; ; jejunum; ; ciliary body; ; left lobe of liver;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleoside-triphosphate diphosphatase activity; nucleotide diphosphatase activity; phosphodiesterase I activity; polysaccharide binding; metal ion binding; scavenger receptor activity; NADH pyrophosphatase activity; catalytic activity; nucleic acid binding; hydrolase activity; calcium ion binding; zinc ion binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; extracellular region; perinuclear region of cytoplasm; extracellular exosome; plasma membrane; external side of plasma membrane; apical plasma membrane;
Biological process	nucleoside triphosphate catabolic process; receptor-mediated endocytosis; immune response; phosphate-containing compound metabolic process; metabolism; inorganic diphosphate transport; nucleic acid phosphodiester bond hydrolysis; basophil activation involved in immune response; pyrimidine nucleotide metabolic process; negative regulation of mast cell activation involved in immune response; ATP metabolic process; negative regulation of inflammatory response; negative regulation of mast cell proliferation; vesicle-mediated transport; endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	5169
	209558
	ENSG00000154269
	ENSMUSG00000019989
	O14638
	Q6DYE8
	NM_005021
	NM_134005; NM_145372
	NP_005012
	NP_598766
	Wikidata
View/Edit Human	View/Edit Mouse

Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 is an enzyme that in humans is encoded by the ENPP3 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154269 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019989 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jin-Hua P, Goding JW, Nakamura H, Sano K (October 1997). "Molecular cloning and chromosomal localization of PD-Ibeta (PDNP3), a new member of the human phosphodiesterase I genes". Genomics. 45 (2): 412–5. doi:10.1006/geno.1997.4949. PMID 9344668.
^ "Entrez Gene: ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154269 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019989 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9344668-5] Jin-Hua P, Goding JW, Nakamura H, Sano K (October 1997). "Molecular cloning and chromosomal localization of PD-Ibeta (PDNP3), a new member of the human phosphodiesterase I genes". Genomics. 45 (2): 412–5. doi:10.1006/geno.1997.4949. PMID 9344668.

[entrez-6] "Entrez Gene: ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3".

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