ENTPD1

ENTPD1
Identifiers
Aliases	ENTPD1, ATPDase, CD39, NTPDase-1, SPG64, ectonucleoside triphosphate diphosphohydrolase 1
External IDs	OMIM: 601752; MGI: 102805; HomoloGene: 20423; GeneCards: ENTPD1; OMA:ENTPD1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	95,877,266 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	40,730,046 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; monocyte; ; popliteal artery; ; tibial arteries; ; tendon of biceps brachii; ; gallbladder; ; right coronary artery; ; urethra; ; blood; ; appendix;
	Top expressed in
	ascending aorta; ; aortic valve; ; granulocyte; ; spermatocyte; ; spermatid; ; atrioventricular valve; ; lens; ; stroma of bone marrow; ; conjunctival fornix; ; carotid body;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; hydrolase activity; ATP binding; nucleoside-diphosphatase activity; nucleoside-triphosphatase activity;
Cellular component	integral component of membrane; integral component of plasma membrane; extracellular exosome; membrane; plasma membrane;
Biological process	cell adhesion; blood coagulation; nucleobase-containing small molecule catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	953
	12495
	ENSG00000138185
	ENSMUSG00000048120
	P49961
	P55772
NM_001098175; NM_001164178; NM_001164179; NM_001164181; NM_001164182;
	NM_001164183; NM_001312654; NM_001776; NM_001320916
	NM_009848; NM_001304721
NP_001091645; NP_001157650; NP_001157651; NP_001157653; NP_001157654;
	NP_001157655; NP_001299583; NP_001307845; NP_001767
	NP_001291650; NP_033978
	Wikidata
View/Edit Human	View/Edit Mouse

Ectonucleoside triphosphate diphosphohydrolase-1 (gene: ENTPD1; protein: NTPDase1) also known as CD39 (Cluster of Differentiation 39), is a typical cell surface enzyme with a catalytic site on the extracellular face.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138185 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048120 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ENTPD1 Ectonucleoside triphosphate diphosphohydrolase 1".
^ Sévigny J, Levesque FP, Grondin G, Beaudoin AR (Feb 1997). "Purification of the blood vessel ATP diphosphohydrolase, identification and localisation by immunological techniques". Biochimica et Biophysica Acta (BBA) - General Subjects. 1334 (1): 73–88. doi:10.1016/s0304-4165(96)00079-7. PMID 9042368.
^ Kaczmarek E, Koziak K, Sévigny J, Siegel JB, Anrather J, Beaudoin AR, Bach FH, Robson SC (Dec 1996). "Identification and characterization of CD39/vascular ATP diphosphohydrolase". The Journal of Biological Chemistry. 271 (51): 33116–22. doi:10.1074/jbc.271.51.33116. PMID 8955160.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138185 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048120 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: ENTPD1 Ectonucleoside triphosphate diphosphohydrolase 1".

[6] Sévigny J, Levesque FP, Grondin G, Beaudoin AR (Feb 1997). "Purification of the blood vessel ATP diphosphohydrolase, identification and localisation by immunological techniques". Biochimica et Biophysica Acta (BBA) - General Subjects. 1334 (1): 73–88. doi:10.1016/s0304-4165(96)00079-7. PMID 9042368.

[7] Kaczmarek E, Koziak K, Sévigny J, Siegel JB, Anrather J, Beaudoin AR, Bach FH, Robson SC (Dec 1996). "Identification and characterization of CD39/vascular ATP diphosphohydrolase". The Journal of Biological Chemistry. 271 (51): 33116–22. doi:10.1074/jbc.271.51.33116. PMID 8955160.

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