Econazole

Econazole
Clinical data
Trade names	Spectazole, Ecostatin, others
AHFS/Drugs.com	Monograph
MedlinePlus	a684049
License data	US DailyMed: Econazole;
Pregnancy; category	AU: A; ;
Routes of; administration	Topical
ATC code	D01AC03 (WHO) G01AF05 (WHO);
Legal status
Legal status	US: ℞-only;
Identifiers
	IUPAC name (RS)-1-{2-[(4-Chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole;
CAS Number	27220-47-9 ;
PubChem CID	3198;
IUPHAR/BPS	2446;
DrugBank	DB01127 ;
ChemSpider	3086 ;
UNII	6Z1Y2V4A7M;
KEGG	D03936 ;
ChEBI	CHEBI:4754 ;
ChEMBL	ChEMBL808 ;
CompTox Dashboard (EPA)	DTXSID2029872 ;
ECHA InfoCard	100.043.932
Chemical and physical data
Formula	C18H15Cl3N2O
Molar mass	381.68 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES Clc1ccc(c(Cl)c1)C(OCc2ccc(Cl)cc2)Cn3ccnc3;
	InChI InChI=1S/C18H15Cl3N2O/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2 ; Key:LEZWWPYKPKIXLL-UHFFFAOYSA-N ;
	(verify)

Econazole is an antifungal medication of the imidazole class.^[3]

It was patented in 1968, and approved for medical use in 1974.^[4]

^ "Econazole topical Use During Pregnancy". Drugs.com. 3 September 2018. Retrieved 31 January 2020.
^ "Spectazole (econazole nitrate 1%) Cream". DailyMed. U.S. National Library of Medicine. 30 September 2013. Retrieved 31 July 2021.
^ Thienpont D, Van Cutsem J, Van Nueten JM, Niemegeers CJ, Marsboom R (February 1975). "Bilogical and toxicological properties of econazole, a broad-spectrum antimycotic". Arzneimittel-Forschung. 25 (2): 224–230. PMID 1173036.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 502. ISBN 9783527607495.