Endergonic reaction

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In chemical thermodynamics, an endergonic reaction (from Greek ἔνδον (endon) 'within', and ἔργον (ergon) 'work'; also called a heat absorbing nonspontaneous reaction or an unfavorable reaction) is a chemical reaction in which the standard change in free energy is positive, and an additional driving force is needed to perform this reaction. In layman's terms, the total amount of useful energy is negative (it takes more energy to start the reaction than what is received out of it) so the total energy is a net negative result, as opposed to a net positive result in an exergonic reaction. Another way to phrase this is that useful energy must be absorbed from the surroundings into the workable system for the reaction to happen.

Under constant temperature and constant pressure conditions, this means that the change in the standard Gibbs free energy would be positive,

${\displaystyle \Delta G^{\circ }>0}$

for the reaction at standard state (i.e. at standard pressure (1 bar), and standard concentrations (1 molar) of all the reagents).

In metabolism, an endergonic process is anabolic, meaning that energy is stored; in many such anabolic processes, energy is supplied by coupling the reaction to adenosine triphosphate (ATP) and consequently resulting in a high energy, negatively charged organic phosphate and positive adenosine diphosphate.