Endoglin

ENG
Identifiers
Aliases	ENG, Eng, AI528660, AI662476, CD105, Endo, S-endoglin, END, HHT1, ORW1, endoglin
External IDs	OMIM: 131195; MGI: 95392; HomoloGene: 92; GeneCards: ENG; OMA:ENG - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.11 Start 127,815,013 bp[1] End 127,854,658 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 B|2 22.09 cM Start 32,536,607 bp[2] End 32,572,681 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung right auricle apex of heart right lobe of thyroid gland left ovary right ovary right coronary artery upper lobe of left lung ascending aorta Descending thoracic aorta Top expressed in lactiferous gland ankle joint right lung choroid plexus of fourth ventricle cardiac muscle tissue of left ventricle right lung lobe external carotid artery Ileal epithelium internal carotid artery right ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function type I transforming growth factor beta receptor binding protein homodimerization activity activin binding transforming growth factor beta-activated receptor activity galactose binding glycosaminoglycan binding BMP binding protein binding transforming growth factor beta binding transmembrane signaling receptor activity type II transforming growth factor beta receptor binding identical protein binding Cellular component integral component of membrane membrane focal adhesion receptor complex endothelial microparticle external side of plasma membrane cell surface extracellular space plasma membrane Biological process cell migration involved in endocardial cushion formation response to hypoxia regulation of transcription, DNA-templated negative regulation of nitric-oxide synthase activity negative regulation of protein autophosphorylation venous blood vessel morphogenesis cell motility positive regulation of pathway-restricted SMAD protein phosphorylation regulation of phosphorylation extracellular matrix disassembly positive regulation of systemic arterial blood pressure wound healing negative regulation of transcription by RNA polymerase II negative regulation of transforming growth factor beta receptor signaling pathway BMP signaling pathway negative regulation of pathway-restricted SMAD protein phosphorylation positive regulation of angiogenesis negative regulation of endothelial cell proliferation vasculogenesis heart looping heart development regulation of cell adhesion cell adhesion negative regulation of cell migration regulation of cell population proliferation angiogenesis artery morphogenesis central nervous system vasculogenesis smooth muscle tissue development positive regulation of BMP signaling pathway branching involved in blood vessel morphogenesis cell chemotaxis transforming growth factor beta receptor signaling pathway cell migration detection of hypoxia regulation of transforming growth factor beta receptor signaling pathway positive regulation of gene expression regulation of cardiac muscle cell apoptotic process bone development positive regulation of protein phosphorylation endocardial cushion to mesenchymal transition sprouting angiogenesis response to corticosteroid extracellular matrix constituent secretion regulation of cell proliferation involved in heart morphogenesis response to transforming growth factor beta positive regulation of collagen biosynthetic process cellular response to mechanical stimulus outflow tract septum morphogenesis epithelial to mesenchymal transition involved in endocardial cushion formation endocardial cushion morphogenesis cardiac ventricle morphogenesis cardiac atrium morphogenesis ventricular trabecula myocardium morphogenesis negative regulation of gene expression dorsal aorta morphogenesis positive regulation of transcription by RNA polymerase II atrial cardiac muscle tissue morphogenesis vascular associated smooth muscle cell development positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of vascular associated smooth muscle cell differentiation atrioventricular canal morphogenesis regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis positive regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2022 13805 Ensembl ENSG00000106991 ENSMUSG00000026814 UniProt P17813 Q96CG0 Q63961 RefSeq (mRNA) NM_000118 NM_001114753 NM_001278138 NM_001146348 NM_001146350 NM_007932 RefSeq (protein) NP_000109 NP_001108225 NP_001265067 NP_001108225.1 NP_001265067.1 NP_001139820 NP_001139822 NP_031958 Location (UCSC) Chr 9: 127.82 – 127.85 Mb Chr 2: 32.54 – 32.57 Mb PubMed search [3] [4]
Wikidata
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Endoglin (ENG) is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex. It is also commonly referred to as CD105, END, FLJ41744, HHT1, ORW and ORW1.^[5] It has a crucial role in angiogenesis, therefore, making it an important protein for tumor growth, survival and metastasis of cancer cells to other locations in the body.