Endothelial NOS

NOS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M9J, 1M9K, 1M9M, 1M9Q, 1M9R, 1NIW, 2LL7, 3EAH, 3NOS, 2MG5, 4D1O, 4D1P
Identifiers
Aliases	NOS3, ECNOS, eNOS, nitric oxide synthase 3
External IDs	OMIM: 163729; MGI: 97362; HomoloGene: 504; GeneCards: NOS3; OMA:NOS3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q36.1 Start 150,991,017 bp[1] End 151,014,588 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 A3|5 11.32 cM Start 24,569,808 bp[2] End 24,589,472 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen apex of heart right auricle upper lobe of left lung left uterine tube left ventricle body of uterus right lobe of thyroid gland left coronary artery right coronary artery Top expressed in right ventricle subcutaneous adipose tissue tunica adventitia of aorta tunica media of zone of aorta white adipose tissue endocardial cushion brown adipose tissue digastric muscle interventricular septum gastrula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function FMN binding actin monomer binding flavin adenine dinucleotide binding scaffold protein binding arginine binding tetrahydrobiopterin binding metal ion binding calmodulin binding protein binding heme binding NADP binding oxidoreductase activity cadmium ion binding nitric-oxide synthase activity NADPH-hemoprotein reductase activity Cellular component cytoplasm endocytic vesicle membrane cytosol Golgi apparatus membrane Golgi membrane plasma membrane caveola cytoskeleton nucleus vesicle membrane Biological process negative regulation of muscle hyperplasia ovulation from ovarian follicle positive regulation of guanylate cyclase activity nitric oxide biosynthetic process regulation of systemic arterial blood pressure by endothelin regulation of sodium ion transport lung development negative regulation of blood pressure removal of superoxide radicals regulation of nitric-oxide synthase activity mitochondrion organization response to heat in utero embryonic development negative regulation of hydrolase activity cell redox homeostasis arginine catabolic process response to fluid shear stress regulation of blood pressure negative regulation of platelet activation blood vessel remodeling negative regulation of extrinsic apoptotic signaling pathway via death domain receptors angiogenesis negative regulation of potassium ion transport nitric oxide mediated signal transduction negative regulation of calcium ion transport smooth muscle hyperplasia regulation of the force of heart contraction by chemical signal endothelial cell migration lipopolysaccharide-mediated signaling pathway negative regulation of cell population proliferation vasodilation positive regulation of blood vessel endothelial cell migration positive regulation of angiogenesis aortic valve morphogenesis pulmonary valve morphogenesis endocardial cushion morphogenesis positive regulation of gene expression homeostasis of number of cells within a tissue ventricular septum morphogenesis negative regulation of biomineral tissue development response to hormone response to lipopolysaccharide regulation of nervous system process positive regulation of Notch signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4846 18127 Ensembl ENSG00000164867 ENSMUSG00000028978 UniProt P29474 P70313 RefSeq (mRNA) NM_000603 NM_001160109 NM_001160110 NM_001160111 NM_008713 RefSeq (protein) NP_000594 NP_001153581 NP_001153582 NP_001153583 NP_032739 Location (UCSC) Chr 7: 150.99 – 151.01 Mb Chr 5: 24.57 – 24.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Endothelial NOS (eNOS), also known as nitric oxide synthase 3 (NOS3) or constitutive NOS (cNOS), is an enzyme that in humans is encoded by the NOS3 gene located in the 7q35-7q36 region of chromosome 7.^[5] This enzyme is one of three isoforms that synthesize nitric oxide (NO), a small gaseous and lipophilic molecule that participates in several biological processes.^[6][7] The other isoforms include neuronal nitric oxide synthase (nNOS), which is constitutively expressed in specific neurons of the brain^[8] and inducible nitric oxide synthase (iNOS), whose expression is typically induced in inflammatory diseases.^[9] eNOS is primarily responsible for the generation of NO in the vascular endothelium,^[10] a monolayer of flat cells lining the interior surface of blood vessels, at the interface between circulating blood in the lumen and the remainder of the vessel wall.^[11] NO produced by eNOS in the vascular endothelium plays crucial roles in regulating vascular tone, cellular proliferation, leukocyte adhesion, and platelet aggregation.^[12] Therefore, a functional eNOS is essential for a healthy cardiovascular system.