Endothelial protein C receptor

PROCR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1L8J, 1LQV, 3JTC, 4V3D, 4V3E
Identifiers
Aliases	PROCR, CCCA, CCD41, EPCR, protein C receptor
External IDs	OMIM: 600646; MGI: 104596; HomoloGene: 4670; GeneCards: PROCR; OMA:PROCR - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	35,216,240 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	155,597,391 bp
RNA expression pattern
	Top expressed in
	pericardium; ; germinal epithelium; ; tendon of biceps brachii; ; gastric mucosa; ; right coronary artery; ; parietal pleura; ; synovial joint; ; vena cava; ; left uterine tube; ; subcutaneous adipose tissue;
	Top expressed in
	decidua; ; endothelial cell of lymphatic vessel; ; gastrula; ; lumbar spinal ganglion; ; semi-lunar valve; ; aortic valve; ; ascending aorta; ; ankle; ; iris; ; atrioventricular valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; signaling receptor activity;
Cellular component	integral component of membrane; extracellular region; cell surface; centrosome; plasma membrane; integral component of plasma membrane; extracellular exosome; membrane; focal adhesion; extracellular space; perinuclear region of cytoplasm;
Biological process	hemostasis; blood coagulation; leukocyte migration; negative regulation of coagulation;
	Sources:Amigo / QuickGO
Orthologs
	10544
	19124
	ENSG00000101000
	ENSMUSG00000027611
	Q9UNN8
	Q64695
	NM_006404
	NM_011171
	NP_006395
	NP_035301
	Wikidata
View/Edit Human	View/Edit Mouse

Endothelial protein C receptor (EPCR) also known as activated protein C receptor (APC receptor) is a protein that in humans is encoded by the PROCR gene.^[5]^[6]^[7] PROCR has also recently been designated CD201 (cluster of differentiation 201).

EPCR is a transmembrane glycoprotein receptor that plays a crucial role in regulation of blood coagulation, inflammation, and vascular integrity. Its ability to enhance the anticoagulant activity of protein C, modulate inflammatory responses, and maintain endothelial barrier function highlights its importance in homeostasis maintanance.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101000 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027611 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fukudome K, Esmon CT (Nov 1994). "Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor". J Biol Chem. 269 (42): 26486–91. doi:10.1016/S0021-9258(18)47220-1. PMID 7929370.
^ Rothbarth K, Dabaghian AR, Stammer H, Werner D (Oct 1999). "One single mRNA encodes the centrosomal protein CCD41 and the endothelial cell protein C receptor (EPCR)". FEBS Lett. 458 (1): 77–80. doi:10.1016/S0014-5793(99)01074-1. PMID 10518938. S2CID 25425851.
^ "Entrez Gene: PROCR protein C receptor, endothelial (EPCR)".
^ Esmon CT (May 2004). "Structure and functions of the endothelial cell protein C receptor". Critical Care Medicine. 32 (Supplement): S298–S301. doi:10.1097/01.CCM.0000126128.64614.81. ISSN 0090-3493. PMID 15118534.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101000 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027611 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7929370-5] Fukudome K, Esmon CT (Nov 1994). "Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor". J Biol Chem. 269 (42): 26486–91. doi:10.1016/S0021-9258(18)47220-1. PMID 7929370.

[pmid10518938-6] Rothbarth K, Dabaghian AR, Stammer H, Werner D (Oct 1999). "One single mRNA encodes the centrosomal protein CCD41 and the endothelial cell protein C receptor (EPCR)". FEBS Lett. 458 (1): 77–80. doi:10.1016/S0014-5793(99)01074-1. PMID 10518938. S2CID 25425851.

[entrez-7] "Entrez Gene: PROCR protein C receptor, endothelial (EPCR)".

[:0-8] Esmon CT (May 2004). "Structure and functions of the endothelial cell protein C receptor". Critical Care Medicine. 32 (Supplement): S298–S301. doi:10.1097/01.CCM.0000126128.64614.81. ISSN 0090-3493. PMID 15118534.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]