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engrailed is a homeodomain transcription factor[1] involved in many aspects of multicellular development. First known for its role in arthropod embryological development, working in consort with the Hox genes, engrailed has been found to be important in other areas of development. It has been identified in many bilaterians, including the arthropods, vertebrates, echinoderms, molluscs, nematodes, brachiopods, and polychaetes.[2] It acts as a "selector" gene, conferring a specific identity to defined areas of the body, and co-ordinating the expression of downstream genes.[3]
- ^ Brunet, I.; Weinl, C.; Piper, M.; Trembleau, A.; Volovitch, M.; Harris, W.; Prochiantz, A.; Holt, C. (2005). "The transcription factor Engrailed-2 guides retinal axons". Nature. 438 (7064): 94–98. Bibcode:2005Natur.438...94B. doi:10.1038/nature04110. PMC 3785142. PMID 16267555.
- ^ Wray, C.; Jacobs, D. K.; Kostriken, R.; Vogler, A. P.; Baker, R.; Desalle, R. (1995). "Homologues of the engrailed gene from five molluscan classes". FEBS Letters. 365 (1): 71–00. doi:10.1016/0014-5793(95)00372-G. PMID 7774719.
- ^ Hidalgo, A. (1994). "Three distinct roles for the engrailed gene in Drosophila wing development". Current Biology. 4 (12): 1087–1098. Bibcode:1994CBio....4.1087H. doi:10.1016/S0960-9822(00)00247-5. PMID 7704572. S2CID 43362521.
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