Back إينتيكافير Arabic انکاویر AZB Entecavir German Entecavir Spanish انتکاویر Persian Entekaviiri Finnish Էնտեկավիր Armenian Entekavir ID Entecavir Italian エンテカビル Japanese

Entecavir

Not to be confused with Emtricitabine.

Entecavir
Clinical data
Pronunciation/ɛnˈtɛkəvɪər/ en-TEK-ə-veer
Trade namesBaraclude, others
Other namesETV, BMS-200475-01
AHFS/Drugs.comMonograph
MedlinePlusa605028
License data
Pregnancy
category
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailabilityn/a (≥70)[3]
Protein binding13% (in vitro)
Metabolismnegligible/nil
Elimination half-life128–149 hours
ExcretionKidney 62–73%
Identifiers
  • 2-Amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1H-purin-6-one
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.111.234 Edit this at Wikidata
Chemical and physical data
FormulaC12H15N5O3
Molar mass277.284 g·mol−1
3D model (JSmol)
Melting point220 °C (428 °F) value applies to entecavir monohydrate and is a minimum value[5]
  • C=C1C(CC(C1CO)O)N2C=NC3=C2N=C(NC3=O)N
  • InChI=1S/C12H15N5O3/c1-5-6(3-18)8(19)2-7(5)17-4-14-9-10(17)15-12(13)16-11(9)20/h4,6-8,18-19H,1-3H2,(H3,13,15,16,20)/t6-,7-,8-/m0/s1 ☒N
  • Key:QDGZDCVAUDNJFG-FXQIFTODSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Entecavir, sold under the brand name Baraclude, is an antiviral medication used in the treatment of hepatitis B virus infection.[6] In those with both HIV/AIDS and hepatitis B virus antiretroviral medication should also be used.[6] Entecavir is taken by mouth as a tablet or solution.[6]

Common side effects include headache, nausea, high blood sugar, and decreased kidney function.[6] Severe side effects include enlargement of the liver, high blood lactate levels, and liver inflammation if the medication is stopped.[6] While there appears to be no harm from use during pregnancy, this use has not been well studied.[1] Entecavir is in the nucleoside reverse transcriptase inhibitors (NRTIs) family of medications.[6][7] It prevents the hepatitis B virus from multiplying by blocking reverse transcriptase.[6]

Entecavir was approved for medical use in 2005.[6] It is on the World Health Organization's List of Essential Medicines.[8] It is available as a generic medication.

  1. ^ a b "Entecavir (Baraclude) Use During Pregnancy". Drugs.com. 3 December 2019. Archived from the original on 7 November 2016. Retrieved 24 January 2021.
  2. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
  3. ^ a b Cite error: The named reference Baraclude FDA label was invoked but never defined (see the help page).
  4. ^ "Baraclude EPAR". European Medicines Agency. 26 June 2006. Archived from the original on 6 March 2024. Retrieved 5 July 2024.
  5. ^ O'Neil MJ (2006). "The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals". The Merck Index (14th ed.). p. 613. ISBN 978-0-911910-00-1.
  6. ^ a b c d e f g h "Entecavir". The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 28 November 2016.
  7. ^ Shetty K, Wu GY (2009). Chronic Viral Hepatitis: Diagnosis and Therapeutics. Springer Science & Business Media. p. 34. ISBN 9781597455657.
  8. ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.

Rich TVX News Network Site

Rich TVX News Network Info

© MMXXIII Rich X Search. We shall prevail. All rights reserved. Rich X Search