Epithelial cell adhesion molecule

EPCAM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4MZV
Identifiers
Aliases	EPCAM, DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1, epithelial cell adhesion molecule, BerEp4, MOC-31, Ber-Ep4
External IDs	OMIM: 185535; MGI: 106653; HomoloGene: 1764; GeneCards: EPCAM; OMA:EPCAM - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	47,387,601 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	87,958,557 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of colon; ; mucosa of sigmoid colon; ; rectum; ; duodenum; ; mucosa of transverse colon; ; renal medulla; ; corpus epididymis; ; islet of Langerhans; ; bronchial epithelial cell;
	Top expressed in
	left colon; ; ileum; ; migratory enteric neural crest cell; ; crypt of lieberkuhn of small intestine; ; epithelium of small intestine; ; intestinal villus; ; duodenum; ; vestibular sensory epithelium; ; utricle; ; medullary collecting duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; protein binding; cadherin binding involved in cell-cell adhesion;
Cellular component	integral component of membrane; lateral plasma membrane; membrane; bicellular tight junction; plasma membrane; cell surface; cell junction; basolateral plasma membrane; apical plasma membrane; extracellular exosome; integral component of plasma membrane;
Biological process	ureteric bud development; positive regulation of cell motility; negative regulation of cell-cell adhesion mediated by cadherin; signal transduction involved in regulation of gene expression; negative regulation of apoptotic process; stem cell differentiation; positive regulation of cell population proliferation; positive regulation of stem cell proliferation; positive regulation of transcription by RNA polymerase II; leukocyte migration; cell-cell adhesion via plasma-membrane adhesion molecules;
	Sources:Amigo / QuickGO
Orthologs
	4072
	17075
	ENSG00000119888
	ENSMUSG00000045394
	P16422
	Q99JW5
	NM_002354
	NM_008532
	NP_002345
	NP_032558
	Wikidata
View/Edit Human	View/Edit Mouse

Epithelial cell adhesion molecule (EpCAM), also known as CD326 among other names, is a transmembrane glycoprotein mediating Ca²⁺-independent homotypic cell–cell adhesion in epithelia.^[5] EpCAM is also involved in cell signaling,^[6] migration,^[7] proliferation, and differentiation.^[8] Additionally, EpCAM has oncogenic potential via its capacity to upregulate c-myc, e-fabp, and cyclins A & E.^[9] Since EpCAM is expressed exclusively in epithelia and epithelial-derived neoplasms, EpCAM can be used as diagnostic marker for various cancers. It appears to play a role in tumorigenesis and metastasis of carcinomas, so it can also act as a potential prognostic marker and as a potential target for immunotherapeutic strategies.^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119888 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045394 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Litvinov SV, Velders MP, Bakker HA, Fleuren GJ, Warnaar SO (April 1994). "Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule". The Journal of Cell Biology. 125 (2): 437–46. doi:10.1083/jcb.125.2.437. PMC 2120036. PMID 8163559.
^ Maetzel D, Denzel S, Mack B, Canis M, Went P, Benk M, et al. (February 2009). "Nuclear signalling by tumour-associated antigen EpCAM". Nature Cell Biology. 11 (2): 162–71. doi:10.1038/ncb1824. PMID 19136966. S2CID 8616872.
^ Osta WA, Chen Y, Mikhitarian K, Mitas M, Salem M, Hannun YA, et al. (August 2004). "EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy". Cancer Research. 64 (16): 5818–24. doi:10.1158/0008-5472.CAN-04-0754. PMID 15313925.
^ Litvinov SV, van Driel W, van Rhijn CM, Bakker HA, van Krieken H, Fleuren GJ, Warnaar SO (March 1996). "Expression of Ep-CAM in cervical squamous epithelia correlates with an increased proliferation and the disappearance of markers for terminal differentiation". The American Journal of Pathology. 148 (3): 865–75. PMC 1861708. PMID 8774141.
^ Münz M, Kieu C, Mack B, Schmitt B, Zeidler R, Gires O (July 2004). "The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation". Oncogene. 23 (34): 5748–58. doi:10.1038/sj.onc.1207610. PMID 15195135. S2CID 32348616.
^ Armstrong A, Eck SL (2003). "EpCAM: A new therapeutic target for an old cancer antigen". Cancer Biology & Therapy. 2 (4): 320–6. doi:10.4161/cbt.2.4.451. PMID 14508099.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119888 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045394 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Litvinov1994-5] Litvinov SV, Velders MP, Bakker HA, Fleuren GJ, Warnaar SO (April 1994). "Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule". The Journal of Cell Biology. 125 (2): 437–46. doi:10.1083/jcb.125.2.437. PMC 2120036. PMID 8163559.

[Maetzel-6] Maetzel D, Denzel S, Mack B, Canis M, Went P, Benk M, et al. (February 2009). "Nuclear signalling by tumour-associated antigen EpCAM". Nature Cell Biology. 11 (2): 162–71. doi:10.1038/ncb1824. PMID 19136966. S2CID 8616872.

[Osta-7] Osta WA, Chen Y, Mikhitarian K, Mitas M, Salem M, Hannun YA, et al. (August 2004). "EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy". Cancer Research. 64 (16): 5818–24. doi:10.1158/0008-5472.CAN-04-0754. PMID 15313925.

[Litvinov1996-8] Litvinov SV, van Driel W, van Rhijn CM, Bakker HA, van Krieken H, Fleuren GJ, Warnaar SO (March 1996). "Expression of Ep-CAM in cervical squamous epithelia correlates with an increased proliferation and the disappearance of markers for terminal differentiation". The American Journal of Pathology. 148 (3): 865–75. PMC 1861708. PMID 8774141.

[9] Münz M, Kieu C, Mack B, Schmitt B, Zeidler R, Gires O (July 2004). "The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation". Oncogene. 23 (34): 5748–58. doi:10.1038/sj.onc.1207610. PMID 15195135. S2CID 32348616.

[Armstrong-10] Armstrong A, Eck SL (2003). "EpCAM: A new therapeutic target for an old cancer antigen". Cancer Biology & Therapy. 2 (4): 320–6. doi:10.4161/cbt.2.4.451. PMID 14508099.

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