| External globus pallidus | |
|---|---|
 External globus pallidus (GPe) seen in 2nd image from the left | |
| Details | |
| Part of | Globus pallidus |
| Identifiers | |
| Latin | globus pallidus externus, globus pallidus lateralis |
| Acronym(s) | GPe |
| NeuroNames | 232 |
| NeuroLex ID | birnlex_1610 |
| TA98 | A14.1.09.509 |
| TA2 | 5570 |
| FMA | 61839 |
| Anatomical terms of neuroanatomy | |
The external globus pallidus (GPe or lateral globus pallidus) combines with the internal globus pallidus (GPi) to form the globus pallidus, an anatomical subset of the basal ganglia. Globus pallidus means "pale globe" in Latin, indicating its appearance. The external globus pallidus is the segment of the globus pallidus that is relatively further (lateral) from the midline of the brain.
The GPe is predominantly composed of inhibitory GABAergic neurons that project axons to the subthalamic nucleus (in the diencephalon), the striatum, internal globus pallidus (GPi) and substantia nigra pars reticulata.[1]
The GPe is particular in comparison to the other elements of the set by the fact that it does not work as an output base of the basal ganglia (not sending axons to the thalamus) but as the main regulator of the basal ganglia system. It is sometimes used as a target for deep brain stimulation as a treatment for Parkinson's disease.
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