F11 receptor

F11R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NBQ, 3EOY, 3TSZ, 4ODB
Identifiers
Aliases	F11R, F11r, 9130004G24, AA638916, ESTM33, JAM, JAM-1, JAM-A, Jcam, Jcam1, Ly106, CD321, JAM1, JAMA, KAT, PAM-1, F11 receptor
External IDs	OMIM: 605721; MGI: 1321398; HomoloGene: 14255; GeneCards: F11R; OMA:F11R - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	161,021,343 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,292,171 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; right lung; ; rectum; ; islet of Langerhans; ; upper lobe of left lung; ; mucosa of transverse colon; ; minor salivary glands; ; gallbladder; ; skin of abdomen; ; left lobe of thyroid gland;
	Top expressed in
	saccule; ; otic placode; ; corneal stroma; ; left lung lobe; ; otic vesicle; ; lactiferous gland; ; choroid plexus of fourth ventricle; ; transitional epithelium of urinary bladder; ; epithelium of stomach; ; large intestine;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	PDZ domain binding; virus receptor activity; protein binding; cadherin binding;
Cellular component	integral component of membrane; membrane; cell-cell junction; bicellular tight junction; plasma membrane; slit diaphragm; extracellular exosome; cytoplasmic vesicle; cell junction;
Biological process	regulation of actin cytoskeleton reorganization; cell differentiation; establishment of endothelial intestinal barrier; epithelial cell differentiation; actomyosin structure organization; extracellular matrix organization; regulation of membrane permeability; regulation of cytokine production; positive regulation of GTPase activity; positive regulation of blood pressure; cell adhesion; negative regulation of GTPase activity; bicellular tight junction assembly; viral entry into host cell; intestinal absorption; response to radiation; inflammatory response; viral process; transforming growth factor beta receptor signaling pathway; leukocyte migration; protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	50848
	16456
	ENSG00000158769
	ENSMUSG00000038235
	Q9Y624
	O88792
NM_016946; NM_144501; NM_144502; NM_144503; NM_144504;
	NM_001348091; NM_001382727; NM_001382730; NM_001382733; NM_001382734
	NM_172647
NP_058642; NP_001335020; NP_001369656; NP_001369659; NP_001369662;
	NP_001369663
	NP_766235
	Wikidata
View/Edit Human	View/Edit Mouse

Junctional adhesion molecule A is a protein that in humans is encoded by the F11R gene.^[5]^[6]^[7] It has also been designated as CD321 (cluster of differentiation 321).

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158769 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038235 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ozaki H, Ishii K, Horiuchi H, Arai H, Kawamoto T, Okawa K, Iwamatsu A, Kita T (Jul 1999). "Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells". Journal of Immunology. 163 (2): 553–7. doi:10.4049/jimmunol.163.2.553. PMID 10395639. S2CID 255364609.
^ Naik UP, Ehrlich YH, Kornecki E (Aug 1995). "Mechanisms of platelet activation by a stimulatory antibody: cross-linking of a novel platelet receptor for monoclonal antibody F11 with the Fc gamma RII receptor". The Biochemical Journal. 310 ( Pt 1) (1): 155–62. doi:10.1042/bj3100155. PMC 1135867. PMID 7646439.
^ "Entrez Gene: F11R F11 receptor".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000158769 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038235 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10395639-5] Ozaki H, Ishii K, Horiuchi H, Arai H, Kawamoto T, Okawa K, Iwamatsu A, Kita T (Jul 1999). "Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells". Journal of Immunology. 163 (2): 553–7. doi:10.4049/jimmunol.163.2.553. PMID 10395639. S2CID 255364609.

[pmid7646439-6] Naik UP, Ehrlich YH, Kornecki E (Aug 1995). "Mechanisms of platelet activation by a stimulatory antibody: cross-linking of a novel platelet receptor for monoclonal antibody F11 with the Fc gamma RII receptor". The Biochemical Journal. 310 ( Pt 1) (1): 155–62. doi:10.1042/bj3100155. PMC 1135867. PMID 7646439.

[entrez-7] "Entrez Gene: F11R F11 receptor".

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