FCAR

FCAR
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1OVZ, 1OW0, 1UCT
Identifiers
Aliases	FCAR, CD89, CTB-61M7.2, FcalphaRI, Fc fragment of IgA receptor, Fc alpha receptor, FcalphaR
External IDs	OMIM: 147045; HomoloGene: 48064; GeneCards: FCAR; OMA:FCAR - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,891,420 bp
RNA expression pattern
	Top expressed in
	monocyte; ; bone marrow; ; bone marrow cells; ; blood; ; right lung; ; granulocyte; ; spleen; ; appendix; ; upper lobe of left lung; ; left uterine tube;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	IgA receptor activity; IgA binding;
Cellular component	integral component of membrane; extracellular region; plasma membrane; integral component of plasma membrane; membrane; specific granule membrane; tertiary granule membrane; ficolin-1-rich granule membrane;
Biological process	immune response; neutrophil degranulation; neutrophil mediated immunity; positive regulation of neutrophil apoptotic process; cellular response to interferon-alpha; Fc receptor signaling pathway; neutrophil activation; cellular response to lipopolysaccharide; cellular response to interferon-gamma; cellular response to interleukin-6; cellular response to tumor necrosis factor; cellular response to granulocyte macrophage colony-stimulating factor stimulus; positive regulation of oxidative stress-induced cell death;
	Sources:Amigo / QuickGO
Orthologs
	2204
	n/a
ENSG00000275564; ENSG00000284004; ENSG00000273738; ENSG00000283953; ENSG00000276985;
	ENSG00000275970; ENSG00000284061; ENSG00000283750; ENSG00000278415; ENSG00000186431; ENSG00000275136; ENSG00000276858; ENSG00000284245; ENSG00000275269; ENSG00000274580
	n/a
	P24071
	n/a
NM_002000; NM_133269; NM_133271; NM_133272; NM_133273;
	NM_133274; NM_133277; NM_133278; NM_133279; NM_133280
	n/a
NP_001991; NP_579803; NP_579805; NP_579806; NP_579807;
	NP_579808; NP_579811; NP_579812
	n/a
	Wikidata
View/Edit Human

Fc fragment of IgA receptor (FCAR) is a human gene^[3] that codes for the transmembrane receptor FcαRI, also known as CD89 (Cluster of Differentiation 89). FcαRI binds the heavy-chain constant region of Immunoglobulin A (IgA) antibodies.^[4] FcαRI is present on the cell surface of myeloid lineage cells, including neutrophils, monocytes, macrophages, and eosinophils,^[5] though it is notably absent from intestinal macrophages^[6] and does not appear on mast cells.^[5] FcαRI plays a role in both pro- and anti-inflammatory responses depending on the state of IgA bound.^[5] Inside-out signaling primes FcαRI in order for it to bind its ligand,^[4] while outside-in signaling caused by ligand binding depends on FcαRI association with the Fc receptor gamma chain (FcR γ-chain).^[5]

Though FcαRI is part of the Fc receptor immunoglobulin superfamily, the protein's primary structure is similar to receptors in the leukocyte receptor cluster (LRC), and the FCAR gene appears amidst LRC genes on chromosome 19.^[4]^[5] This contrasts with the location of other members of the Fc receptor immunoglobulin superfamily, which are encoded on chromosome 1.^[4]^[5] Additionally, though there are equivalents to FCAR in several species, there is no such homolog in mice.^[4]

^ ^a ^b ^c ENSG00000284004, ENSG00000273738, ENSG00000283953, ENSG00000276985, ENSG00000275970, ENSG00000284061, ENSG00000283750, ENSG00000278415, ENSG00000186431, ENSG00000275136, ENSG00000276858, ENSG00000284245, ENSG00000275269, ENSG00000274580 GRCh38: Ensembl release 89: ENSG00000275564, ENSG00000284004, ENSG00000273738, ENSG00000283953, ENSG00000276985, ENSG00000275970, ENSG00000284061, ENSG00000283750, ENSG00000278415, ENSG00000186431, ENSG00000275136, ENSG00000276858, ENSG00000284245, ENSG00000275269, ENSG00000274580 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: FCAR Fc fragment of IgA, receptor for".
^ ^a ^b ^c ^d ^e Bakema JE, van Egmond M (November 2011). "The human immunoglobulin A Fc receptor FcαRI: a multifaceted regulator of mucosal immunity". Mucosal Immunology. 4 (6): 612–24. doi:10.1038/mi.2011.36. PMID 21937986.
^ ^a ^b ^c ^d ^e ^f Aleyd E, Heineke MH, van Egmond M (November 2015). "The era of the immunoglobulin A Fc receptor FcαRI; its function and potential as target in disease". Immunological Reviews. 268 (1): 123–38. doi:10.1111/imr.12337. PMID 26497517. S2CID 21300390.
^ Smith PD, Smythies LE, Mosteller-Barnum M, Sibley DA, Russell MW, Merger M, Sellers MT, Orenstein JM, Shimada T, Graham MF, Kubagawa H (September 2001). "Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities". Journal of Immunology. 167 (5): 2651–6. doi:10.4049/jimmunol.167.5.2651. PMID 11509607.

[refGRCh38Ensembl-1] ENSG00000284004, ENSG00000273738, ENSG00000283953, ENSG00000276985, ENSG00000275970, ENSG00000284061, ENSG00000283750, ENSG00000278415, ENSG00000186431, ENSG00000275136, ENSG00000276858, ENSG00000284245, ENSG00000275269, ENSG00000274580 GRCh38: Ensembl release 89: ENSG00000275564, ENSG00000284004, ENSG00000273738, ENSG00000283953, ENSG00000276985, ENSG00000275970, ENSG00000284061, ENSG00000283750, ENSG00000278415, ENSG00000186431, ENSG00000275136, ENSG00000276858, ENSG00000284245, ENSG00000275269, ENSG00000274580 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez22-3] "Entrez Gene: FCAR Fc fragment of IgA, receptor for".

[Bakema_2011-4] Bakema JE, van Egmond M (November 2011). "The human immunoglobulin A Fc receptor FcαRI: a multifaceted regulator of mucosal immunity". Mucosal Immunology. 4 (6): 612–24. doi:10.1038/mi.2011.36. PMID 21937986.

[Aleyd_2015-5] ^ ^a ^b ^c ^d ^e ^f Aleyd E, Heineke MH, van Egmond M (November 2015). "The era of the immunoglobulin A Fc receptor FcαRI; its function and potential as target in disease". Immunological Reviews. 268 (1): 123–38. doi:10.1111/imr.12337. PMID 26497517. S2CID 21300390.

[6] Smith PD, Smythies LE, Mosteller-Barnum M, Sibley DA, Russell MW, Merger M, Sellers MT, Orenstein JM, Shimada T, Graham MF, Kubagawa H (September 2001). "Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities". Journal of Immunology. 167 (5): 2651–6. doi:10.4049/jimmunol.167.5.2651. PMID 11509607.

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