FCGR2B

FCGR2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FCB, 3WJJ,%%s3WJL
Identifiers
Aliases	FCGR2B, CD32, CD32B, FCG2, FCGR2, IGFR2, Fc fragment of IgG receptor IIb, FcRII-c, FCGR2C
External IDs	OMIM: 604590; MGI: 95499; HomoloGene: 2974; GeneCards: FCGR2B; OMA:FCGR2B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	161,678,654 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	170,804,116 bp
RNA expression pattern
	Top expressed in
	placenta; ; right coronary artery; ; blood; ; spleen; ; monocyte; ; lymph node; ; synovial membrane; ; synovial joint; ; granulocyte; ; appendix;
	Top expressed in
	stroma of bone marrow; ; tibiofemoral joint; ; calvaria; ; granulocyte; ; skin of abdomen; ; blood; ; spleen; ; right kidney; ; molar; ; motor neuron;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; IgG binding; amyloid-beta binding; low-affinity IgG receptor activity; protein-containing complex binding; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane; external side of plasma membrane; dendritic spine; cell body; cytoplasm;
Biological process	viral process; immune response; signal transduction; regulation of immune response; negative regulation of type I hypersensitivity; negative regulation of antibody-dependent cellular cytotoxicity; follicular dendritic cell activation; mature B cell differentiation involved in immune response; follicular B cell differentiation; immune complex clearance by monocytes and macrophages; negative regulation of dendritic cell antigen processing and presentation; regulation of B cell antigen processing and presentation; negative regulation of immunoglobulin production; regulation of adaptive immune response; negative regulation of acute inflammatory response to antigenic stimulus; positive regulation of humoral immune response; negative regulation of humoral immune response mediated by circulating immunoglobulin; receptor-mediated endocytosis; phagocytosis, engulfment; defense response; inflammatory response; response to bacterium; regulation of signaling receptor activity; immunoglobulin mediated immune response; antigen processing and presentation of exogenous peptide antigen via MHC class II; cerebellum development; negative regulation of B cell proliferation; negative regulation of interleukin-10 production; Fc-gamma receptor signaling pathway involved in phagocytosis; negative regulation of macrophage activation; negative regulation of cytotoxic T cell degranulation; regulation of innate immune response; mast cell activation; positive regulation of JNK cascade; negative regulation of phagocytosis; positive regulation of phagocytosis; negative regulation of immune response; negative regulation of B cell receptor signaling pathway; negative regulation of B cell activation; cellular response to molecule of bacterial origin; regulation of immune complex clearance by monocytes and macrophages; positive regulation of neuron death; negative regulation of neutrophil activation; regulation of dendritic spine maintenance; cellular response to amyloid-beta; positive regulation of response to endoplasmic reticulum stress; negative regulation of dendritic cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	2213
	14130
	ENSG00000072694
	ENSMUSG00000026656
	P31994; P31995
	P08101
	NM_001002273; NM_001002274; NM_001002275; NM_001190828; NM_004001
	NM_001077189; NM_010187
NP_001002273; NP_001002274; NP_001002275; NP_001177757; NP_003992;
	NP_963857
	NP_001070657; NP_034317
	Wikidata
View/Edit Human	View/Edit Mouse

Fc fragment of IgG receptor IIb (coded by FCGR2B gene) is a low affinity inhibitory receptor for the Fc region of immunoglobulin gamma (IgG). FCGR2B participates in the phagocytosis of immune complexes and in the regulation of antibody production by B lymphocytes.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000072694 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026656 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "FCGR2B Fc fragment of IgG receptor IIb [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-06-14.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000072694 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026656 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "FCGR2B Fc fragment of IgG receptor IIb [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-06-14.

[1]

[2]

[3]

[4]

[5]