FCRL3

FCRL3
Identifiers
Aliases	FCRL3, CD307c, FCRH3, IFGP3, IRTA3, SPAP2, Fc receptor like 3
External IDs	OMIM: 606510; HomoloGene: 76447; GeneCards: FCRL3; OMA:FCRL3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	157,700,769 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; granulocyte; ; lymph node; ; spleen; ; appendix; ; testicle; ; blood; ; epithelium of nasopharynx; ; tonsil; ; bone marrow cells;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	kinase binding; phosphatase binding; protein phosphatase binding; protein tyrosine kinase binding;
Cellular component	membrane; integral component of membrane; plasma membrane; cell surface;
Biological process	negative regulation of immunoglobulin production; positive regulation of B cell proliferation; regulation of toll-like receptor 9 signaling pathway; positive regulation of MAPK cascade; regulation of B cell differentiation; negative regulation of B cell receptor signaling pathway; regulation of B cell activation; regulation of calcium ion import; positive regulation of protein serine/threonine phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	115352
	n/a
	ENSG00000160856
	n/a
	Q96P31
	n/a
	NM_001024667; NM_052939; NM_001320333
	n/a
	NP_001307262; NP_443171
	n/a
	Wikidata
View/Edit Human

Fc receptor-like protein 3 is a protein that in humans is encoded by the FCRL3 gene.^[3]^[4]^[5]

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motif (ITAM) and immunoreceptor-tyrosine inhibitory motif (ITIM) in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160856 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Davis RS, Wang YH, Kubagawa H, Cooper MD (August 2001). "Identification of a family of Fc receptor homologs with preferential B cell expression". Proceedings of the National Academy of Sciences of the United States of America. 98 (17): 9772–7. Bibcode:2001PNAS...98.9772D. doi:10.1073/pnas.171308498. PMC 55528. PMID 11493702.
^ Davis RS, Dennis G Jr, Kubagawa H, Cooper MD (May 2002). "Fc Receptor Homologs (FcRH1-5) Extend the Fc Receptor Family". The Interface Between Innate and Acquired Immunity. Current Topics in Microbiology and Immunology. Vol. 266. pp. 85–112. doi:10.1007/978-3-662-04700-2_7. ISBN 978-3-642-07682-4. PMID 12014205. {{cite book}}: |journal= ignored (help)
^ ^a ^b "Entrez Gene: FCRL3 Fc receptor-like 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160856 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11493702-3] Davis RS, Wang YH, Kubagawa H, Cooper MD (August 2001). "Identification of a family of Fc receptor homologs with preferential B cell expression". Proceedings of the National Academy of Sciences of the United States of America. 98 (17): 9772–7. Bibcode:2001PNAS...98.9772D. doi:10.1073/pnas.171308498. PMC 55528. PMID 11493702.

[pmid12014205-4] Davis RS, Dennis G Jr, Kubagawa H, Cooper MD (May 2002). "Fc Receptor Homologs (FcRH1-5) Extend the Fc Receptor Family". The Interface Between Innate and Acquired Immunity. Current Topics in Microbiology and Immunology. Vol. 266. pp. 85–112. doi:10.1007/978-3-662-04700-2_7. ISBN 978-3-642-07682-4. PMID 12014205. {{cite book}}: |journal= ignored (help)

[entrez-5] "Entrez Gene: FCRL3 Fc receptor-like 3".

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