FI6 (antibody)

FI6 is an antibody that targets a protein found on the surface of all influenza A viruses called hemagglutinin. FI6 is the only known antibody found to bind all 16 subtypes of the influenza A virus hemagglutinin and is hoped to be useful for a universal influenza virus therapy.^[1]^[2]^[3]

The antibody binds to the F domain HA trimer, and prevents the virus from attaching to the host cell. The antibody has been refined in order to remove any excess, unstable mutations that could negatively affect its neutralising ability, and this new version of the antibody has been termed "FI6v3"^[4]

^ Gallagher, James (29 July 2011). "'Super antibody' fights off flu". BBC.
^ Laurance, Jeremy (29 July 2011). "Scientists hail the prospect of a universal vaccine for flu". Independent.
^ Chan AL (28 July 2011). "Universal Flu Vaccine On The Horizon: Researchers Find 'Super Antibody'". Huff Post.
^ Corti, D; Voss, J; Gamblin, SJ; Codoni, G; Macagno, A; Jarrossay, D; Vachieri, SG; Pinna, D; Minola, A; Vanzetta, F; Silacci, C; Fernandez-Rodriguez, BM; Agatic, G; Bianchi, S; Giacchetto-Sasselli, I; Calder, L; Sallusto, F; Collins, P; Haire, LF; Temperton, N; Langedijk, JP; Skehel, JJ; Lanzavecchia, A (12 August 2011). "A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins". Science Magazine. 333 (6044): 850–6. Bibcode:2011Sci...333..850C. doi:10.1126/science.1205669. PMID 21798894. S2CID 5086468.

[BBC-1] Gallagher, James (29 July 2011). "'Super antibody' fights off flu". BBC.

[Independent-2] Laurance, Jeremy (29 July 2011). "Scientists hail the prospect of a universal vaccine for flu". Independent.

[Huffington-3] Chan AL (28 July 2011). "Universal Flu Vaccine On The Horizon: Researchers Find 'Super Antibody'". Huff Post.

[Corti_et_al,_2011-4] Corti, D; Voss, J; Gamblin, SJ; Codoni, G; Macagno, A; Jarrossay, D; Vachieri, SG; Pinna, D; Minola, A; Vanzetta, F; Silacci, C; Fernandez-Rodriguez, BM; Agatic, G; Bianchi, S; Giacchetto-Sasselli, I; Calder, L; Sallusto, F; Collins, P; Haire, LF; Temperton, N; Langedijk, JP; Skehel, JJ; Lanzavecchia, A (12 August 2011). "A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins". Science Magazine. 333 (6044): 850–6. Bibcode:2011Sci...333..850C. doi:10.1126/science.1205669. PMID 21798894. S2CID 5086468.

[1]

[2]

[3]

[4]