Factor XIII

coagulation factor XIII, A1 polypeptide
Inactive A1 peptide homodimer with all of the domains and main catalytic residues shown with different colors.
Identifiers
Symbol	F13A1
Alt. symbols	F13A
NCBI gene	2162
HGNC	3531
OMIM	134570
RefSeq	NM_000129
UniProt	P00488
Other data
EC number	2.3.2.13
Locus	Chr. 6 p24.2-p23
Search for Structures Swiss-model Domains InterPro

Factor XIII, or fibrin stabilizing factor, is a plasma protein and zymogen. It is activated by thrombin to factor XIIIa which crosslinks fibrin in coagulation. Deficiency of XIII worsens clot stability and increases bleeding tendency.^[1]

Human XIII is a heterotetramer. It consists of 2 enzymatic A peptides and 2 non-enzymatic B peptides. XIIIa is a dimer of activated A peptides.^[1]