Fas receptor

FAS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DDF, 3EWT, 3EZQ, 3THM, 3TJE, 2NA7
Identifiers
Aliases	FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6, Fas cell surface death receptor
External IDs	OMIM: 134637; MGI: 95484; HomoloGene: 27; GeneCards: FAS; OMA:FAS - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.31 Start 88,953,813 bp[1] End 89,029,605 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C1|19 29.48 cM Start 34,290,666 bp[2] End 34,327,772 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum left ovary right ovary gallbladder epithelium of nasopharynx right lung left adrenal gland stromal cell of endometrium right adrenal cortex left adrenal cortex Top expressed in granulocyte thymus right lung lobe tunica media of zone of aorta seminal vesicula intercostal muscle duodenum jejunum brown adipose tissue white adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase binding protein binding transmembrane signaling receptor activity signal transducer activity identical protein binding tumor necrosis factor-activated receptor activity tumor necrosis factor binding calmodulin binding signaling receptor activity Cellular component CD95 death-inducing signaling complex membrane extracellular region cell surface extracellular exosome integral component of membrane plasma membrane integral component of plasma membrane external side of plasma membrane death-inducing signaling complex membrane raft cytosol nuclear body mitochondrion Biological process renal system process activation-induced cell death of T cells tumor necrosis factor-mediated signaling pathway T cell homeostasis positive regulation of extrinsic apoptotic signaling pathway in absence of ligand cellular response to mechanical stimulus circadian rhythm apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway via death domain receptors activation of cysteine-type endopeptidase activity involved in apoptotic process apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway spleen development negative thymic T cell selection regulation of lymphocyte differentiation necroptotic signaling pathway motor neuron apoptotic process inflammatory response regulation of myeloid cell differentiation protein homooligomerization response to toxic substance B cell mediated immunity neuron apoptotic process positive regulation of protein homooligomerization cellular response to lithium ion positive regulation of lymphocyte apoptotic process negative regulation of apoptotic process immune response gene expression cellular response to hyperoxia negative regulation of B cell activation response to glucocorticoid extrinsic apoptotic signaling pathway in absence of ligand inflammatory cell apoptotic process immunoglobulin production signal transduction hepatocyte apoptotic process response to lipopolysaccharide extrinsic apoptotic signaling pathway regulation of apoptotic process positive regulation of apoptotic process regulation of cell population proliferation negative regulation of extrinsic apoptotic signaling pathway via death domain receptors multicellular organism development extrinsic apoptotic signaling pathway via death domain receptors positive regulation of protein phosphorylation regulation of stress-activated MAPK cascade cellular response to amino acid starvation Fas signaling pathway positive regulation of apoptotic signaling pathway positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 355 14102 Ensembl ENSG00000026103 ENSMUSG00000024778 UniProt P25445 P25446 RefSeq (mRNA) NM_000043 NM_152871 NM_152872 NM_152873 NM_152874 NM_152875 NM_152876 NM_152877 NM_001320619 NM_001146708 NM_007987 RefSeq (protein) NP_000034 NP_001307548 NP_690610 NP_690611 NP_001140180 NP_032013 Location (UCSC) Chr 10: 88.95 – 89.03 Mb Chr 19: 34.29 – 34.33 Mb PubMed search [3] [4]
Wikidata
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The Fas receptor, also known as Fas, FasR, apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6), is a protein that in humans is encoded by the FAS gene.^[5][6] Fas was first identified using a monoclonal antibody generated by immunizing mice with the FS-7 cell line. Thus, the name Fas is derived from FS-7-associated surface antigen.^[7]

The Fas receptor is a death receptor on the surface of cells that leads to programmed cell death (apoptosis) if it binds its ligand, Fas ligand (FasL). It is one of two apoptosis pathways, the other being the mitochondrial pathway.^[8]