Felodipine

Felodipine
Clinical data
Trade names	Plendil
AHFS/Drugs.com	Monograph
MedlinePlus	a692016
Routes of; administration	Oral
ATC code	C08CA02 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	15%
Metabolism	Hepatic
Onset of action	2.5–5 hours
Elimination half-life	25 hours
Excretion	Renal
Identifiers
	IUPAC name (RS)-3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;
CAS Number	72509-76-3 ;
PubChem CID	3333;
IUPHAR/BPS	4190;
DrugBank	DB01023 ;
ChemSpider	3216 ;
UNII	OL961R6O2C;
KEGG	D00319 ;
ChEBI	CHEBI:585948 ;
ChEMBL	ChEMBL1480 ;
CompTox Dashboard (EPA)	DTXSID4023042 ;
ECHA InfoCard	100.149.305
Chemical and physical data
Formula	C18H19Cl2NO4
Molar mass	384.25 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC)\C1=C(\N/C(=C(/C(=O)OC)C1c2cccc(Cl)c2Cl)C)C;
	InChI InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3 ; Key:RZTAMFZIAATZDJ-UHFFFAOYSA-N ;
	(verify)

Felodipine is a medication of the calcium channel blocker type that is used to treat high blood pressure.

It was patented in 1978, and approved for medical use in 1988.^[2]

^ "Felopidine UK label". UK Electronic Medicines Compendium. 15 September 2015. Archived from the original on 16 August 2019. Retrieved 19 February 2015.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 465. ISBN 9783527607495.