Fibrillin

fibrillin 1
fibrillin 1
	Crystallographic structure of the cbEGF9-hybrid2-cbEGF10 region of human fibrillin 1.
Identifiers
Symbol	FBN1
Alt. symbols	FBN, MFS1, WMS
NCBI gene	2200
HGNC	3603
OMIM	134797
PDB	2W86
RefSeq	NM_000138
UniProt	P35555
Other data
Locus	Chr. 15 q21.1
Structures
Search for
Structures	Swiss-model
Domains	InterPro

fibrillin 3

Identifiers

Symbol

FBN3

Other data

Search for
Structures	Swiss-model
Domains	InterPro

Fibrillin is a glycoprotein, which is essential for the formation of elastic fibers found in connective tissue.^[2] Fibrillin is secreted into the extracellular matrix by fibroblasts and becomes incorporated into the insoluble microfibrils, which appear to provide a scaffold for deposition of elastin.^[3]

^ PDB: 2W86; Jensen SA, Iqbal S, Lowe ED, Redfield C, Handford PA (May 2009). "Structure and interdomain interactions of a hybrid domain: a disulphide-rich module of the fibrillin/LTBP superfamily of matrix proteins". Structure. 17 (5): 759–68. doi:10.1016/j.str.2009.03.014. PMC 2724076. PMID 19446531.
^ Kielty CM, Baldock C, Lee D, Rock MJ, Ashworth JL, Shuttleworth CA (February 2002). "Fibrillin: from microfibril assembly to biomechanical function". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 357 (1418): 207–17. doi:10.1098/rstb.2001.1029. PMC 1692929. PMID 11911778.
^ Singh (2006). Textbook of human histology. Jaypee Brothers Publishers. pp. 64–. ISBN 978-81-8061-809-3. Retrieved 9 December 2010.^{[permanent dead link]}