Fibroblast growth factor receptor 2

FGFR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DJS, 1E0O, 1EV2, 1GJO, 1II4, 1IIL, 1NUN, 1OEC, 1WVZ, 2FDB, 2PSQ, 2PVF, 2PVY, 2PWL, 2PY3, 2PZ5, 2PZP, 2PZR, 2Q0B, 3B2T, 3CAF, 3CLY, 3CU1, 3DAR, 3EUU, 3OJ2, 3OJM, 3RI1, 4J95, 4J96, 4J97, 4J98, 4J99, 4J23, 4WV1
Identifiers
Aliases	FGFR2, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, fibroblast growth factor receptor 2
External IDs	OMIM: 176943; MGI: 95523; HomoloGene: 22566; GeneCards: FGFR2; OMA:FGFR2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.13 Start 121,478,332 bp[1] End 121,598,458 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 129,764,181 bp[2] End 132,725,079 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment corpus callosum inferior olivary nucleus ventricular zone parotid gland inferior ganglion of vagus nerve external globus pallidus subthalamic nucleus substantia nigra skin of thigh Top expressed in calvaria genital tubercle adrenal gland ventricular zone left lung lobe choroid plexus of fourth ventricle epithelium of trachea retinal pigment epithelium medullary collecting duct wall of esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparin binding kinase activity transmembrane receptor protein tyrosine kinase activity fibroblast growth factor binding ATP binding protein kinase activity fibroblast growth factor-activated receptor activity transferase activity protein homodimerization activity protein binding nucleotide binding protein tyrosine kinase activity 1-phosphatidylinositol-3-kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity identical protein binding receptor tyrosine kinase transmembrane signaling receptor activity Cellular component cytoplasm membrane extracellular region nucleus cell surface integral component of membrane Golgi apparatus intracellular membrane-bounded organelle extracellular matrix plasma membrane nucleoplasm cell cortex integral component of plasma membrane excitatory synapse cytoplasmic vesicle receptor complex collagen-containing extracellular matrix Biological process fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development ureteric bud development organ growth limb bud formation embryonic pattern specification bud elongation involved in lung branching positive regulation of canonical Wnt signaling pathway membranous septum morphogenesis fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow embryonic organ morphogenesis post-embryonic development squamous basal epithelial stem cell differentiation involved in prostate gland acinus development branching morphogenesis of a nerve reproductive structure development fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell ventricular cardiac muscle tissue morphogenesis protein phosphorylation positive regulation of cardiac muscle cell proliferation mesenchymal cell differentiation positive regulation of mesenchymal cell proliferation regulation of osteoblast differentiation prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis angiogenesis prostate gland morphogenesis positive regulation of ERK1 and ERK2 cascade orbitofrontal cortex development negative regulation of epithelial cell proliferation animal organ morphogenesis embryonic digestive tract morphogenesis hair follicle morphogenesis morphogenesis of embryonic epithelium branch elongation involved in salivary gland morphogenesis apoptotic process branching involved in salivary gland morphogenesis cell fate commitment lung development embryonic organ development fibroblast growth factor receptor signaling pathway involved in hemopoiesis in utero embryonic development lateral sprouting from an epithelium positive regulation of Wnt signaling pathway gland morphogenesis positive regulation of cell cycle branching involved in labyrinthine layer morphogenesis branching involved in prostate gland morphogenesis regulation of ERK1 and ERK2 cascade protein autophosphorylation mammary gland bud formation pyramidal neuron development lacrimal gland development positive regulation of MAPK cascade regulation of smooth muscle cell differentiation regulation of cell fate commitment bone mineralization regulation of branching involved in prostate gland morphogenesis positive regulation of epithelial cell proliferation involved in lung morphogenesis epithelial cell differentiation phosphorylation multicellular organism growth positive regulation of epithelial cell proliferation ventricular zone neuroblast division epidermis morphogenesis skeletal system morphogenesis regulation of morphogenesis of a branching structure negative regulation of transcription by RNA polymerase II outflow tract septum morphogenesis odontogenesis epithelial to mesenchymal transition lung alveolus development lung lobe morphogenesis midbrain development positive regulation of smooth muscle cell proliferation fibroblast growth factor receptor signaling pathway involved in mammary gland specification mesenchymal cell proliferation involved in lung development prostate epithelial cord elongation mesenchymal cell differentiation involved in lung development axonogenesis regulation of multicellular organism growth otic vesicle formation epithelial cell proliferation involved in salivary gland morphogenesis cell-cell signaling regulation of fibroblast growth factor receptor signaling pathway bone morphogenesis MAPK cascade regulation of osteoblast proliferation positive regulation of phospholipase activity fibroblast growth factor receptor signaling pathway regulation of smoothened signaling pathway inner ear morphogenesis positive regulation of cell population proliferation mesodermal cell differentiation peptidyl-tyrosine phosphorylation digestive tract development lung-associated mesenchyme development bone development positive regulation of cell division positive regulation of transcription by RNA polymerase II phosphatidylinositol phosphate biosynthetic process phosphatidylinositol-3-phosphate biosynthetic process endochondral bone growth response to lipopolysaccharide wound healing cellular response to fibroblast growth factor stimulus response to ethanol cellular response to retinoic acid cellular response to transforming growth factor beta stimulus embryonic cranial skeleton morphogenesis positive regulation of protein kinase B signaling negative regulation of signal transduction cell differentiation negative regulation of apoptotic process transmembrane receptor protein tyrosine kinase signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2263 14183 Ensembl ENSG00000066468 ENSMUSG00000030849 UniProt P21802 P21803 RefSeq (mRNA) NM_000141 NM_001144913 NM_001144914 NM_001144915 NM_001144916 NM_001144917 NM_001144918 NM_001144919 NM_022970 NM_022971 NM_022972 NM_022973 NM_022974 NM_022975 NM_022976 NM_023028 NM_023029 NM_023030 NM_001320654 NM_001320658 NM_023031 NM_010207 NM_201601 NM_001347638 RefSeq (protein) NP_000132 NP_001138385 NP_001138386 NP_001138387 NP_001138388 NP_001138389 NP_001138390 NP_001138391 NP_001307583 NP_001307587 NP_075259 NP_075418 NP_001334567 NP_034337 NP_963895 Location (UCSC) Chr 10: 121.48 – 121.6 Mb Chr 7: 129.76 – 132.73 Mb PubMed search [3] [4]
Wikidata
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Fibroblast growth factor receptor 2 (FGFR-2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10.^[5][6] FGFR2 is a receptor for fibroblast growth factor.

FGFR-2 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution.^[7] FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform.