Back خلايا متغصنة جرابية Arabic Cèl·lula dendrítica fol·licular Catalan Folikulární dendritická buňka Czech Célula dendrítica folicular Spanish Célula dendrítica folicular Galician Sel dendritik folikuler ID 濾胞樹状細胞 Japanese Célula dendrítica folicular Portuguese Фолликулярные дендритные клетки Russian Follicular dendritic cell Thai

Follicular dendritic cells

Histologic comparison of cell types in a germinal center, H&E stain:
- Centrocytes are small to medium size with angulated, elongated, cleaved, or twisted nuclei.
- Centroblasts are larger cells containing vesicular nuclei with one to three basophilic nucleoli apposing the nuclear membrane.
- Follicular dendritic cells have round nuclei, centrally located nucleoli, bland and dispersed chromatin, and flattening of adjacent nuclear membrane.

Follicular dendritic cells (FDC) are cells of the immune system found in primary and secondary lymph follicles (lymph nodes) of the B cell areas of the lymphoid tissue.[1][2][3] Unlike dendritic cells (DC), FDCs are not derived from the bone-marrow hematopoietic stem cell, but are of mesenchymal origin.[4] Possible functions of FDC include: organizing lymphoid tissue's cells and microarchitecture, capturing antigen to support B cell, promoting debris removal from germinal centers, and protecting against autoimmunity. Disease processes that FDC may contribute include primary FDC-tumor, chronic inflammatory conditions, HIV-1 infection development, and neuroinvasive scrapie.

  1. ^ Liu Y, Grouard G, de Bouteiller O, Banchereau J (1996). Follicular dendritic cells and germinal centers. International Review of Cytology. Vol. 166. pp. 139–79. doi:10.1016/S0074-7696(08)62508-5. ISBN 978-0-12-364570-8. PMID 8881775. {{cite book}}: |journal= ignored (help)
  2. ^ Heesters, Balthasar A.; Myers, Riley C.; Carroll, Michael C. (2014-06-20). "Follicular dendritic cells: dynamic antigen libraries". Nature Reviews Immunology. 14 (7): 495–504. doi:10.1038/nri3689. ISSN 1474-1733. PMID 24948364. S2CID 7082877.
  3. ^ Aguzzi, Adriano; Kranich, Jan; Krautler, Nike Julia (March 2014). "Follicular dendritic cells: origin, phenotype, and function in health and disease". Trends in Immunology. 35 (3): 105–113. doi:10.1016/j.it.2013.11.001. ISSN 1471-4906. PMID 24315719.
  4. ^ Banchereau J, Steinman RM (1998). "Dendritic cells and the control of immunity". Nature. 392 (6673): 245–52. Bibcode:1998Natur.392..245B. doi:10.1038/32588. PMID 9521319. S2CID 4388748.van Nierop K, de Groot C (2002). "Human follicular dendritic cells: function, origin and development". Semin Immunol. 14 (4): 251–7. doi:10.1016/S1044-5323(02)00057-X. PMID 12163300.

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