Frizzled-4

FZD4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5BPB, 5BPQ, 5BQC, 5BQE, 5CL1, 5CM4
Identifiers
Aliases	FZD4, CD344, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4, frizzled class receptor 4
External IDs	OMIM: 604579; MGI: 108520; HomoloGene: 7325; GeneCards: FZD4; OMA:FZD4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	86,955,395 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	89,062,342 bp
RNA expression pattern
	Top expressed in
	adipose tissue; ; subcutaneous adipose tissue; ; right lung; ; abdominal fat; ; parietal pleura; ; synovial joint; ; tendon of biceps brachii; ; pericardium; ; seminal vesicula; ; thoracic diaphragm;
	Top expressed in
	retinal pigment epithelium; ; choroid plexus of fourth ventricle; ; ciliary body; ; internal carotid artery; ; Epithelium of choroid plexus; ; epithelium of stomach; ; ankle; ; subcutaneous adipose tissue; ; white adipose tissue; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	PDZ domain binding; protein homodimerization activity; signal transducer activity; protein binding; protein heterodimerization activity; Wnt-activated receptor activity; ubiquitin protein ligase binding; transmembrane signaling receptor activity; cytokine binding; G protein-coupled receptor activity; Wnt-protein binding; amyloid-beta binding; signaling receptor activity; protein-containing complex binding;
Cellular component	clathrin-coated endocytic vesicle membrane; membrane; cell-cell junction; plasma membrane; integral component of plasma membrane; cell surface; extracellular exosome; integral component of membrane; clathrin-coated vesicle membrane; dendrite; synapse; glutamatergic synapse;
Biological process	negative regulation of cell-substrate adhesion; cellular response to retinoic acid; G protein-coupled receptor signaling pathway; luteinization; extracellular matrix-cell signaling; positive regulation of JUN kinase activity; positive regulation of DNA-binding transcription factor activity; hearing; Wnt signaling pathway; regulation of vascular endothelial growth factor receptor signaling pathway; vasculogenesis; positive regulation of transcription, DNA-templated; multicellular organism development; cerebellum vasculature morphogenesis; cell surface receptor signaling pathway; progesterone secretion; blood vessel development; neuron differentiation; retinal blood vessel morphogenesis; canonical Wnt signaling pathway; substrate adhesion-dependent cell spreading; locomotion involved in locomotory behavior; retina vasculature morphogenesis in camera-type eye; signal transduction; Wnt signaling pathway, calcium modulating pathway; Wnt signaling pathway, planar cell polarity pathway; membrane organization; non-canonical Wnt signaling pathway; positive regulation of neuron projection arborization; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	8322
	14366
	ENSG00000174804
	ENSMUSG00000049791
	Q9ULV1
	Q61088
	NM_012193
	NM_008055
	NP_036325
	NP_032081
	Wikidata
View/Edit Human	View/Edit Mouse

Frizzled-4 (Fz-4) is a protein that in humans is encoded by the FZD4 gene.^[5]^[6]^[7] Fz-4 has also been designated as CD344 (cluster of differentiation 344).

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174804 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049791 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kirikoshi H, Sagara N, Koike J, Tanaka K, Sekihara H, Hirai M, Katoh M (Nov 1999). "Molecular cloning and characterization of human Frizzled-4 on chromosome 11q14-q21". Biochemical and Biophysical Research Communications. 264 (3): 955–61. doi:10.1006/bbrc.1999.1612. PMID 10544037.
^ Toomes C, Bottomley HM, Jackson RM, Towns KV, Scott S, Mackey DA, Craig JE, Jiang L, Yang Z, Trembath R, Woodruff G, Gregory-Evans CY, Gregory-Evans K, Parker MJ, Black GC, Downey LM, Zhang K, Inglehearn CF (Apr 2004). "Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q". American Journal of Human Genetics. 74 (4): 721–30. doi:10.1086/383202. PMC 1181948. PMID 15024691.
^ "Entrez Gene: FZD4 frizzled homolog 4 (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174804 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049791 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10544037-5] Kirikoshi H, Sagara N, Koike J, Tanaka K, Sekihara H, Hirai M, Katoh M (Nov 1999). "Molecular cloning and characterization of human Frizzled-4 on chromosome 11q14-q21". Biochemical and Biophysical Research Communications. 264 (3): 955–61. doi:10.1006/bbrc.1999.1612. PMID 10544037.

[pmid15024691-6] Toomes C, Bottomley HM, Jackson RM, Towns KV, Scott S, Mackey DA, Craig JE, Jiang L, Yang Z, Trembath R, Woodruff G, Gregory-Evans CY, Gregory-Evans K, Parker MJ, Black GC, Downey LM, Zhang K, Inglehearn CF (Apr 2004). "Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q". American Journal of Human Genetics. 74 (4): 721–30. doi:10.1086/383202. PMC 1181948. PMID 15024691.

[entrez-7] "Entrez Gene: FZD4 frizzled homolog 4 (Drosophila)".

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