Gastrointestinal stromal tumor

Gastrointestinal stromal tumor
Gastrointestinal stromal tumor
	Histopathologic image of gastrointestinal stromal tumor of the stomach. Hematoxylin-eosin stain.
Specialty	Oncology
Differential diagnosis	Ectopic pancreas

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. GISTs arise in the smooth muscle pacemaker interstitial cell of Cajal, or similar cells.^[2] They are defined as tumors whose behavior is driven by mutations in the KIT gene (85%),^[2] PDGFRA gene (10%),^[2] or BRAF kinase (rare).^[2] 95% of GISTs stain positively for KIT (CD117).^[2]^[3] Most (66%) occur in the stomach and gastric GISTs have a lower malignant potential than tumors found elsewhere in the GI tract.^[3]

^ Yuan, Z; Chen, J; Zheng, Q; Huang, XY; Yang, Z; Tang, J (7 August 2009). "Heterotopic pancreas in the gastrointestinal tract". World Journal of Gastroenterology. 15 (29): 3701–3. doi:10.3748/wjg.15.3701. PMC 2721251. PMID 19653355.
^ ^a ^b ^c ^d ^e Cite error: The named reference DeVita_2011_9 was invoked but never defined (see the help page).
^ ^a ^b Cite error: The named reference Miettinen2006 was invoked but never defined (see the help page).

[Yuan-1] Yuan, Z; Chen, J; Zheng, Q; Huang, XY; Yang, Z; Tang, J (7 August 2009). "Heterotopic pancreas in the gastrointestinal tract". World Journal of Gastroenterology. 15 (29): 3701–3. doi:10.3748/wjg.15.3701. PMC 2721251. PMID 19653355.

[DeVita_2011_9-2] Cite error: The named reference DeVita_2011_9 was invoked but never defined (see the help page).

[Miettinen2006-3] Cite error: The named reference Miettinen2006 was invoked but never defined (see the help page).

[1]

[2]

[3]