| glycophorin C (Gerbich blood group) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | GYPC | ||||||
| Alt. symbols | GPC, GYPD, Ge, CD236, CD236R | ||||||
| NCBI gene | 2995 | ||||||
| HGNC | 4704 | ||||||
| OMIM | 110750 | ||||||
| RefSeq | NM_002101 | ||||||
| UniProt | P04921 | ||||||
| Other data | |||||||
| Locus | Chr. 2 q14-q21 | ||||||
| |||||||
Glycophorin C (GYPC; CD236/CD236R; glycoprotein beta; glycoconnectin; PAS-2') plays a functionally important role in maintaining erythrocyte shape and regulating membrane material properties, possibly through its interaction with protein 4.1. Moreover, it has previously been shown that membranes deficient in protein 4.1 exhibit decreased content of glycophorin C. It is also an integral membrane protein of the erythrocyte and acts as the receptor for the Plasmodium falciparum protein PfEBP-2 (erythrocyte binding protein 2; baebl; EBA-140).
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