Glycoprotein IIb/IIIa

integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Identifiers
Symbol	ITGB3
Alt. symbols	GP3A
NCBI gene	3690
HGNC	6156
OMIM	173470
RefSeq	NM_000212
UniProt	P05106
Other data
Locus	Chr. 17 q21.32
Structures
Search for
Structures	Swiss-model
Domains	InterPro

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Structures	Swiss-model
Domains	InterPro

integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Identifiers
Symbol	ITGA2B
Alt. symbols	GP2B
NCBI gene	3674
HGNC	6138
OMIM	607759
RefSeq	NM_000419
UniProt	P08514
Other data
Locus	Chr. 17 q21.32
Structures
Search for
Structures	Swiss-model
Domains	InterPro

In biochemistry and medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin α_IIbβ₃) is an integrin complex found on platelets. It is a transmembrane receptor for fibrinogen^[1] and von Willebrand factor, and aids platelet activation. The complex is formed via calcium-dependent association of gpIIb and gpIIIa, a required step in normal platelet aggregation and endothelial adherence.^[2]^[3] Platelet activation by ADP (blocked by clopidogrel) leads to the aforementioned conformational change in platelet gpIIb/IIIa receptors that induces binding to fibrinogen.^[1] The gpIIb/IIIa receptor is a target of several drugs including abciximab, eptifibatide, and tirofiban.

^ ^a ^b Vickers JD (July 1999). "Binding of polymerizing fibrin to integrin alpha(IIb)beta(3) on chymotrypsin-treated rabbit platelets decreases phosphatidylinositol 4,5-bisphosphate and increases cytoskeletal actin". Platelets. 10 (4): 228–37. doi:10.1080/09537109976077. PMID 16801097.
^ Calvete JJ (April 1995). "On the structure and function of platelet integrin alpha IIb beta 3, the fibrinogen receptor". Proceedings of the Society for Experimental Biology and Medicine. 208 (4): 346–60. doi:10.3181/00379727-208-43863a. PMID 7535429. S2CID 9298838.
^ Shattil SJ (August 1999). "Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways". Thrombosis and Haemostasis. 82 (2): 318–25. doi:10.1055/s-0037-1615849. PMID 10605720. S2CID 83902334.

[Vickers_1999-1] Vickers JD (July 1999). "Binding of polymerizing fibrin to integrin alpha(IIb)beta(3) on chymotrypsin-treated rabbit platelets decreases phosphatidylinositol 4,5-bisphosphate and increases cytoskeletal actin". Platelets. 10 (4): 228–37. doi:10.1080/09537109976077. PMID 16801097.

[pmid7535429-2] Calvete JJ (April 1995). "On the structure and function of platelet integrin alpha IIb beta 3, the fibrinogen receptor". Proceedings of the Society for Experimental Biology and Medicine. 208 (4): 346–60. doi:10.3181/00379727-208-43863a. PMID 7535429. S2CID 9298838.

[pmid10605720-3] Shattil SJ (August 1999). "Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways". Thrombosis and Haemostasis. 82 (2): 318–25. doi:10.1055/s-0037-1615849. PMID 10605720. S2CID 83902334.

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