Gonadoblastoma

Gonadoblastoma
Gonadoblastoma
	Micrograph of a gonadoblastoma. H&E stain.
Specialty	Urology, oncology

A gonadoblastoma is a complex neoplasm composed of a mixture of gonadal elements,^[1] such as large primordial germ cells, immature Sertoli cells or granulosa cells of the sex cord, and gonadal stromal cells. Gonadoblastomas are by definition benign, but more than 50% have a co-existing dysgerminoma which is malignant, and an additional 10% have other more aggressive malignancies, and as such are often treated as malignant.^[2]

^ Cools M, Stoop H, Kersemaekers AM, Drop SL, Wolffenbuttel KP, Bourguignon JP, et al. (June 2006). "Gonadoblastoma arising in undifferentiated gonadal tissue within dysgenetic gonads". The Journal of Clinical Endocrinology and Metabolism. 91 (6): 2404–2413. doi:10.1210/jc.2005-2554. hdl:1854/LU-848144. PMID 16608895.
^ Ehdaivand S, Gupta N (2 July 2014). "Gonadoblastoma". PathologyOutlines.com.

[pmid16608895-1] Cools M, Stoop H, Kersemaekers AM, Drop SL, Wolffenbuttel KP, Bourguignon JP, et al. (June 2006). "Gonadoblastoma arising in undifferentiated gonadal tissue within dysgenetic gonads". The Journal of Clinical Endocrinology and Metabolism. 91 (6): 2404–2413. doi:10.1210/jc.2005-2554. hdl:1854/LU-848144. PMID 16608895.

[2] Ehdaivand S, Gupta N (2 July 2014). "Gonadoblastoma". PathologyOutlines.com.

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