Granulocyte-macrophage colony-stimulating factor receptor

CSF2RA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NKQ, 4RS1
Identifiers
Aliases	CSF2RA, CD116, CDw116, CSF2R, CSF2RAX, CSF2RAY, CSF2RX, CSF2RY, GM-CSF-R-alpha, GMCSFR, GMR, SMDP4, colony stimulating factor 2 receptor alpha subunit, alphaGMR, colony stimulating factor 2 receptor subunit alpha, GMR-alpha, GMCSFR-alpha, granulocyte-macrophage colony-stimulating factor receptor
External IDs	OMIM: 425000, 306250; MGI: 1339754; HomoloGene: 48406; GeneCards: CSF2RA; OMA:CSF2RA - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band X;Y Start 1,268,800 bp[1] End 1,310,381 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 D3|19 56.89 cM Start 61,223,957 bp[2] End 61,228,429 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood granulocyte placenta sural nerve right lung testicle upper lobe of left lung C1 segment appendix Top expressed in granulocyte tibiofemoral joint stroma of bone marrow neural layer of retina genital tubercle superior frontal gyrus blood subcutaneous adipose tissue primary visual cortex spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cytokine receptor activity protein tyrosine kinase activity signaling receptor activity cytokine binding Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane extracellular region intracellular anatomical structure external side of plasma membrane receptor complex Biological process MAPK cascade peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1438 12982 Ensembl ENSG00000198223 ENSMUSG00000059326 UniProt P15509 Q00941 RefSeq (mRNA) NM_001161529 NM_001161530 NM_001161531 NM_001161532 NM_006140 NM_172245 NM_172246 NM_172247 NM_172248 NM_172249 NM_001379153 NM_001379154 NM_001379155 NM_001379156 NM_001379158 NM_001379159 NM_001379160 NM_001379161 NM_001379162 NM_001379163 NM_001379164 NM_001379165 NM_001379166 NM_001379167 NM_001379168 NM_001379169 NM_009970 RefSeq (protein) NP_001155001 NP_001155002 NP_001155003 NP_001155004 NP_006131 NP_758448 NP_758449 NP_758450 NP_758452 NP_001366082 NP_001366083 NP_001366084 NP_001366085 NP_001366087 NP_001366088 NP_001366089 NP_001366090 NP_001366091 NP_001366092 NP_001366093 NP_001366094 NP_001366095 NP_001366096 NP_001366097 NP_001366098 NP_034100 Location (UCSC) Chr X: 1.27 – 1.31 Mb Chr 19: 61.22 – 61.23 Mb PubMed search [3] [4]
Wikidata
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The granulocyte-macrophage colony-stimulating factor receptor, also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte-macrophage colony-stimulating factor, which stimulates the production of white blood cells.^[5] In contrast to M-CSF and G-CSF which are lineage specific, GM-CSF and its receptor play a role in earlier stages of development. The receptor is primarily located on neutrophils, eosinophils and monocytes/macrophages, it is also on CD34+ progenitor cells (myeloblasts) and precursors for erythroid and megakaryocytic lineages, but only in the beginning of their development.^[5][6]

It is associated with Surfactant metabolism dysfunction type 4.