Granulocyte colony-stimulating factor

CSF3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D9Q, 1CD9, 1GNC, 1PGR, 1RHG
Identifiers
Aliases	CSF3, C17orf33, CSF3OS, GCSF, colony stimulating factor 3
External IDs	OMIM: 138970; MGI: 1339751; HomoloGene: 7677; GeneCards: CSF3; OMA:CSF3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.1 Start 40,015,361 bp[1] End 40,017,813 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 62.45 cM Start 98,592,089 bp[2] End 98,594,455 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle olfactory zone of nasal mucosa vena cava muscle of thigh gastrocnemius muscle left uterine tube cartilage tissue upper lobe of left lung mucosa of paranasal sinus gonad Top expressed in entorhinal cortex embryo CA3 field lactiferous gland cervix endothelial cell of lymphatic vessel medulla oblongata primary motor cortex blastocyst integument More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity enzyme binding growth factor activity granulocyte colony-stimulating factor receptor binding Cellular component extracellular region extracellular space Biological process positive regulation of protein kinase B signaling positive regulation of actin filament polymerization cellular response to cytokine stimulus positive regulation of peptidyl-serine phosphorylation multicellular organism development granulocyte differentiation immune response positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of protein binding cellular response to lipopolysaccharide positive regulation of actin cytoskeleton reorganization positive regulation of transcription by RNA polymerase II negative regulation of neuron death positive regulation of myeloid cell differentiation response to ethanol positive regulation of cell population proliferation neutrophil differentiation macrophage differentiation myeloid cell development regulation of signaling receptor activity cytokine-mediated signaling pathway positive regulation of DNA-binding transcription factor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1440 12985 Ensembl ENSG00000108342 ENSMUSG00000038067 UniProt P09919 P09920 RefSeq (mRNA) NM_000759 NM_001178147 NM_172219 NM_172220 NM_009971 RefSeq (protein) NP_000750 NP_001171618 NP_757373 NP_757374 NP_034101 Location (UCSC) Chr 17: 40.02 – 40.02 Mb Chr 11: 98.59 – 98.59 Mb PubMed search [3] [4]
Wikidata
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Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream.^[5][6]

Functionally, it is a cytokine and hormone, a type of colony-stimulating factor, and is produced by a number of different tissues. The pharmaceutical analogs of naturally occurring G-CSF are called filgrastim and lenograstim.

G-CSF also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils.