HAVCR2

HAVCR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5F71
Identifiers
Aliases	HAVCR2, HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3, CD366, hepatitis A virus cellular receptor 2, SPTCL
External IDs	OMIM: 606652; MGI: 2159682; HomoloGene: 129541; GeneCards: HAVCR2; OMA:HAVCR2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	157,142,869 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	46,372,082 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; appendix; ; blood; ; spleen; ; C1 segment; ; lymph node; ; amniotic fluid; ; upper lobe of left lung; ; decidua;
	Top expressed in
	gastrula; ; decidua; ; stroma of bone marrow; ; spleen; ; lumbar subsegment of spinal cord; ; embryo; ; endothelial cell of lymphatic vessel; ; superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein binding;
Cellular component	integral component of membrane; membrane; cell junction; early endosome; immunological synapse; cell surface; mediator complex;
Biological process	negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; negative regulation of defense response to bacterium; negative regulation of interferon-gamma production; negative regulation of immunological synapse formation; adaptive immune response; maternal process involved in female pregnancy; positive regulation of cytokine production; negative regulation of natural killer cell activation; immune system process; negative regulation of immune response to tumor cell; negative regulation of interleukin-6 production; negative regulation of granulocyte colony-stimulating factor production; natural killer cell tolerance induction; positive regulation of interferon-gamma production; positive regulation of macrophage activation; regulation of tolerance induction dependent upon immune response; negative regulation of T-helper 1 type immune response; positive regulation of defense response to bacterium; positive regulation of interleukin-4 production; negative regulation of gene expression; positive regulation of NIK/NF-kappaB signaling; negative regulation of myeloid dendritic cell activation; macrophage activation involved in immune response; negative regulation of T cell proliferation; positive regulation of T cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of innate immune response; negative regulation of interferon-alpha production; negative regulation of innate immune response; positive regulation of chemokine production; negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; negative regulation of tumor necrosis factor production; toll-like receptor 9 signaling pathway; negative regulation of type I interferon production; innate immune response; inflammatory response; negative regulation of interleukin-3 production; negative regulation of NF-kappaB transcription factor activity; toll-like receptor 3 signaling pathway; negative regulation of interleukin-2 production; cellular response to lipopolysaccharide; positive regulation of interleukin-1 production; toll-like receptor 7 signaling pathway; defense response to Gram-positive bacterium; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	84868
	171285
	ENSG00000135077
	ENSMUSG00000020399
	Q8TDQ0
	Q8VIM0
	NM_032782
	NM_134250
	NP_116171
	NP_599011
	Wikidata
View/Edit Human	View/Edit Mouse

Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein that in humans is encoded by the HAVCR2 (TIM-3)gene. HAVCR2 was first described in 2002 as a cell surface molecule expressed on IFNγ producing CD4+ Th1 and CD8+ Tc1 cells.^[5]^[6] Later, the expression was detected in Th17 cells,^[7] regulatory T-cells,^[8] and innate immune cells (dendritic cells, NK cells, monocytes).^[9] HAVCR2 receptor is a regulator of the immune response.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135077 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020399 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, et al. (January 2002). "Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease". Nature. 415 (6871): 536–541. doi:10.1038/415536a. PMID 11823861. S2CID 4403803.
^ "Entrez Gene: HAVCR2 hepatitis A virus cellular receptor 2".
^ Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, et al. (September 2009). "TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines". European Journal of Immunology. 39 (9): 2492–2501. doi:10.1002/eji.200939274. PMC 2759376. PMID 19676072.
^ Gao X, Zhu Y, Li G, Huang H, Zhang G, Wang F, et al. (2012). "TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression". PLOS ONE. 7 (2): e30676. Bibcode:2012PLoSO...730676G. doi:10.1371/journal.pone.0030676. PMC 3281852. PMID 22363469.
^ Gleason MK, Lenvik TR, McCullar V, Felices M, O'Brien MS, Cooley SA, et al. (March 2012). "Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9". Blood. 119 (13): 3064–3072. doi:10.1182/blood-2011-06-360321. PMC 3321868. PMID 22323453.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135077 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020399 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11823861-5] Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, et al. (January 2002). "Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease". Nature. 415 (6871): 536–541. doi:10.1038/415536a. PMID 11823861. S2CID 4403803.

[entrez-6] "Entrez Gene: HAVCR2 hepatitis A virus cellular receptor 2".

[7] Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, et al. (September 2009). "TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines". European Journal of Immunology. 39 (9): 2492–2501. doi:10.1002/eji.200939274. PMC 2759376. PMID 19676072.

[Gao_2012-8] Gao X, Zhu Y, Li G, Huang H, Zhang G, Wang F, et al. (2012). "TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression". PLOS ONE. 7 (2): e30676. Bibcode:2012PLoSO...730676G. doi:10.1371/journal.pone.0030676. PMC 3281852. PMID 22363469.

[9] Gleason MK, Lenvik TR, McCullar V, Felices M, O'Brien MS, Cooley SA, et al. (March 2012). "Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9". Blood. 119 (13): 3064–3072. doi:10.1182/blood-2011-06-360321. PMC 3321868. PMID 22323453.

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