HER2

ERBB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MFG, 1MFL, 1MW4, 1N8Z, 1QR1, 1S78, 2A91, 2JWA, 2KS1, 2L4K, 3BE1, 3H3B, 3N85, 3PP0, 3RCD, 3MZW, 3WLW, 3WSQ, 4GFU, 4HRL, 4HRM, 4HRN, 2N2A
Identifiers
Aliases	ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 2
External IDs	OMIM: 164870; MGI: 95410; HomoloGene: 3273; GeneCards: ERBB2; OMA:ERBB2 - orthologs
EC number	2.7.10.1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 39,687,914 bp[1] End 39,730,426 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 61.75 cM|11 D Start 98,303,296 bp[2] End 98,328,542 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube sural nerve skin of leg skin of abdomen renal medulla minor salivary glands right lobe of thyroid gland olfactory zone of nasal mucosa mucosa of transverse colon left lobe of thyroid gland Top expressed in lip intestinal villus middle ear Eustachian tube oral mucosa esophagus colon crypt of lieberkuhn of small intestine right kidney left colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ErbB-3 class receptor binding transferase activity nucleotide binding protein kinase activity protein dimerization activity growth factor binding RNA polymerase I core binding kinase activity protein C-terminus binding protein binding identical protein binding protein heterodimerization activity transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity protein phosphatase binding ATP binding transmembrane signaling receptor activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity receptor tyrosine kinase Cellular component integral component of membrane membrane myelin sheath receptor complex plasma membrane basolateral plasma membrane apical plasma membrane perinuclear region of cytoplasm endosome membrane cytoplasmic vesicle nucleus cytoplasm cytosol integral component of plasma membrane basal plasma membrane Biological process positive regulation of protein phosphorylation peripheral nervous system development regulation of transcription, DNA-templated negative regulation of immature T cell proliferation in thymus positive regulation of MAP kinase activity phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of epithelial cell proliferation cellular response to growth factor stimulus wound healing oligodendrocyte differentiation regulation of angiogenesis positive regulation of translation transcription, DNA-templated nervous system development MAPK cascade protein phosphorylation heart development cell surface receptor signaling pathway positive regulation of GTPase activity positive regulation of cell growth regulation of microtubule-based process neuromuscular junction development regulation of ERK1 and ERK2 cascade myelination protein autophosphorylation phosphatidylinositol 3-kinase signaling positive regulation of transcription by RNA polymerase I cell population proliferation positive regulation of transcription by RNA polymerase III motor neuron axon guidance enzyme linked receptor protein signaling pathway signal transduction positive regulation of cell adhesion positive regulation of protein targeting to membrane ERBB2 signaling pathway phosphatidylinositol phosphate biosynthetic process positive regulation of gene expression peptidyl-tyrosine phosphorylation regulation of cell motility cellular response to epidermal growth factor stimulus regulation of transcription by RNA polymerase II negative regulation of ERBB signaling pathway positive regulation of protein kinase B signaling negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade intracellular signal transduction positive regulation of cell population proliferation neuron differentiation positive regulation of MAPK cascade Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2064 13866 Ensembl ENSG00000141736 ENSMUSG00000062312 UniProt P04626 P70424 RefSeq (mRNA) NM_001005862 NM_001289936 NM_001289937 NM_001289938 NM_004448 NM_001003817 NM_010152 RefSeq (protein) NP_001005862 NP_001276865 NP_001276866 NP_001276867 NP_004439 NP_001369711 NP_001369712 NP_001369713 NP_001369714 NP_001369715 NP_001369716 NP_001369717 NP_001369718 NP_001369719 NP_001369720 NP_001369721 NP_001369722 NP_001369723 NP_001369724 NP_001369725 NP_001369726 NP_001369727 NP_001369728 NP_001369729 NP_001369730 NP_001369731 NP_001369732 NP_001369733 NP_001369734 NP_001369735 NP_001003817 Location (UCSC) Chr 17: 39.69 – 39.73 Mb Chr 11: 98.3 – 98.33 Mb PubMed search [3] [4]
Wikidata
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Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 (cluster of differentiation 340).^[5][6][7]

HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. But contrary to other members of the ERBB family, HER2 does not directly bind ligand. HER2 activation results from heterodimerization with another ERBB member or by homodimerization when HER2 concentration are high, for instance in cancer.^[8] Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients.^[9]