HLA-A11

HLA-A11
HLA-A11
(MHC Class I, A cell surface antigen)
	Rendering of A11 (A*1101-B2M) in complex with HBV peptide homologue2HN7 HLA-A11 'alpha chain' (Cyan), β2-microglobulin (Rose), HBV peptide (yellow).
About
Protein	transmembrane receptor/ligand
Structure	αβ heterodimer
Subunits	HLA-A*11--, β2-microglobulin
Older names	HL-A11
Subtypes
Subtype
Subtype	allele
A11E, A11.1	*1101
A11K, A11.2	*1102
Rare alleles
Subtype
Subtype	allele
A11.3	*1103
A11.4	*1104
	Alleles link-out to IMGT/HLA database at EBI

HLA-A11 (A11) is a human leukocyte antigen serotype within HLA-A "A" serotype group. The serotype is determined by the antibody recognition of α¹¹ subset of HLA-A α-chains. For A11, the alpha "A" chain are encoded by the HLA-A*11 allele group and the β-chain are encoded by B2M locus.^[1] This group currently is dominated by A*1101. A11 and A*11 are almost synonymous in meaning. A11 is more common in East Asia than elsewhere, it is part of several long haplotypes that appear to have been frequent in the ancient peoples of Asia.^[2]

^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
^ de Campos-Lima PO, Levitsky V, Brooks J, et al. (April 1994). "T cell responses and virus evolution: loss of HLA A11-restricted CTL epitopes in Epstein-Barr virus isolates from highly A11-positive populations by selective mutation of anchor residues". J. Exp. Med. 179 (4): 1297–305. doi:10.1084/jem.179.4.1297. PMC 2191457. PMID 7511684.

[pmid77067-1] Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.

[pmid7511684-2] Campos-Lima PO, Levitsky V, Brooks J, et al. (April 1994). "T cell responses and virus evolution: loss of HLA A11-restricted CTL epitopes in Epstein-Barr virus isolates from highly A11-positive populations by selective mutation of anchor residues". J. Exp. Med. 179 (4): 1297–305. doi:10.1084/jem.179.4.1297. PMC 2191457. PMID 7511684.

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