HLA-B27

HLA-B*2705-peptide (chain A shown in green cartoon, chain B shown in yellow cartoon) complexed to a fragment of the influenza nucleoprotein NP383-391 (orange, sticks). PDB ID 2BST
B*2705-β2MG with bound peptide 2bst




major histocompatibility complex (human), class I, B27
Alleles	B*2701, 2702, 2703, . . .
Structure (See HLA-B)		Available 3D structures
EBI-HLA	B*2701 Archived 2009-02-20 at the Wayback Machine
	B*2702 Archived 2009-02-20 at the Wayback Machine
	B*2703 Archived 2009-02-20 at the Wayback Machine
	B*2704 Archived 2009-02-20 at the Wayback Machine
	B*2705 Archived 2009-02-20 at the Wayback Machine	2bsr, 2bss, 2bst, 2a83, 1w0v, 1uxs, 1ogt, 1hsa, 1jgd, 1jge
	B*2706 Archived 2009-02-20 at the Wayback Machine
	B*2709 Archived 2009-02-20 at the Wayback Machine	1w0w, 1uxw, 1of2, 1k5n

Human leukocyte antigen (HLA) B27 (subtypes B*2701-2759)^[1] is a class I surface molecule encoded by the B locus in the major histocompatibility complex (MHC) on chromosome 6 and presents antigenic peptides (derived from self and non-self antigens) to T cells. HLA-B27 is strongly associated with ankylosing spondylitis and other associated inflammatory diseases, such as psoriatic arthritis, inflammatory bowel disease, and reactive arthritis.

^ M. A. Khan (2010). "HLA and spondyloarthropathies". In Narinder K. Mehra (ed.). The HLA Complex in Biology and Medicine. New Delhi, India: Jayppee Brothers Medical Publishers. pp. 259–275. ISBN 978-81-8448-870-8.