Hepatitis E virus

Hepatitis E virus
	TEM micrograph of Hepatitis E virus virions
Virus classification
(unranked):	Virus
Realm:	Riboviria
Kingdom:	Orthornavirae
Phylum:	Kitrinoviricota
Class:	Alsuviricetes
Order:	Hepelivirales
Family:	Hepeviridae
Genus:	Paslahepevirus
Species:	Paslahepevirus balayani
Synonyms
	Hepatitis E virus; Orthohepavirus A;

Hepatitis E virus (HEV) is the causative agent of hepatitis E.^[2]^[3]

Globally, approximately 939 million corresponding to 1 in 8 individuals have ever experienced HEV infection. About 15–110 million individuals have recent or ongoing HEV infection.^[4] The virus particle was first seen in 1983,^[5] but was only molecularly cloned in 1989.^[6]

^ "History of the taxon: Species: Paslahepevirus balayani (2024 Release, MSL #40)". International Committee on Taxonomy of Viruses. Retrieved 8 March 2025.
^ "Hepeviridae - Hepeviridae - Positive-sense RNA Viruses - ICTV". www.ictv.global.
^ Purdy, Michael A.; et al. (June 2014). "New Classification Scheme for Hepeviridae" (PDF). International Committee on Taxonomy of Viruses (ICTV). Retrieved 1 May 2019. The species Hepatitis E virus will be renamed Orthohepevirus A, and the species Avian hepatitis E virus will be renamed Orthohepevirus B.
^ Li P, Liu J, Li Y, Su J, Ma Z, Bramer WM, Cao W, de Man RA, Peppelenbosch MP, Pan Q (July 2020). "The global epidemiology of hepatitis E virus infection: A systematic review and meta-analysis". Liver International. 40 (7): 1516–1528. doi:10.1111/liv.14468. PMC 7384095. PMID 32281721.
^ Balayan MS, Andjaparidze AG, Savinskaya SS, et al. (1983). "Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route". Intervirology. 20 (1): 23–31. doi:10.1159/000149370. PMID 6409836.
^ Reyes GR, Purdy MA, Kim JP, et al. (1990). "Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis". Science. 247 (4948): 1335–9. Bibcode:1990Sci...247.1335R. doi:10.1126/science.2107574. PMID 2107574.

[ictvhistory-1] "History of the taxon: Species: Paslahepevirus balayani (2024 Release, MSL #40)". International Committee on Taxonomy of Viruses. Retrieved 8 March 2025.

[ICTVReport-2] "Hepeviridae - Hepeviridae - Positive-sense RNA Viruses - ICTV". www.ictv.global.

[2014.008a-hV-3] Purdy, Michael A.; et al. (June 2014). "New Classification Scheme for Hepeviridae" (PDF). International Committee on Taxonomy of Viruses (ICTV). Retrieved 1 May 2019. The species Hepatitis E virus will be renamed Orthohepevirus A, and the species Avian hepatitis E virus will be renamed Orthohepevirus B.

[Li2020-4] Li P, Liu J, Li Y, Su J, Ma Z, Bramer WM, Cao W, de Man RA, Peppelenbosch MP, Pan Q (July 2020). "The global epidemiology of hepatitis E virus infection: A systematic review and meta-analysis". Liver International. 40 (7): 1516–1528. doi:10.1111/liv.14468. PMC 7384095. PMID 32281721.

[:0-5] Balayan MS, Andjaparidze AG, Savinskaya SS, et al. (1983). "Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route". Intervirology. 20 (1): 23–31. doi:10.1159/000149370. PMID 6409836.

[6] Reyes GR, Purdy MA, Kim JP, et al. (1990). "Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis". Science. 247 (4948): 1335–9. Bibcode:1990Sci...247.1335R. doi:10.1126/science.2107574. PMID 2107574.

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